ReviewBiochemical Society transactions2016
Construction of membrane-bound artificial cells using microfluidics: a new frontier in bottom-up synthetic biology.
Review in Biochemical Society transactions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- QuantGUV: Quantifying Encapsulation Efficiency of Small Molecules in Giant Unilamellar Vesicles.ACS applied materials & interfaces · 2026Article
- Artificial cells and biomimicry cells: A rising star in the fight against cancer.Materials today. Bio · 2025Review
- Synthetic cells for phage therapy: a perspective.Frontiers in cellular and infection microbiology · 2025Review
- Imaging-Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids.Advanced healthcare materials · 2024Review
- Regulation of species metabolism in synthetic community systems by environmental pH oscillations.Nature communications · 2023Article
- Recent advances in microfluidic-based cancer immunotherapy-on-a-chip strategies.Biomicrofluidics · 2023Review
- Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application.Pharmaceutics · 2022Review
- A Microfluidic Platform for Sequential Assembly and Separation of Synthetic Cell Models.ACS synthetic biology · 2021Article
- A Modular, Dynamic, DNA-Based Platform for Regulating Cargo Distribution and Transport between Lipid Domains.Nano letters · 2021Article
- Interfacing Living and Synthetic Cells as an Emerging Frontier in Synthetic Biology.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Review
- Interfacing Living and Synthetic Cells as an Emerging Frontier in Synthetic Biology.Angewandte Chemie (International ed. in English) · 2021Review
- Prebiological Membranes and Their Role in the Emergence of Early Cellular Life.The Journal of membrane biology · 2020Review
- On-Chip Inverted Emulsion Method for Fast Giant Vesicle Production, Handling, and Analysis.Micromachines · 2020Article
- Microfluidics for Artificial Life: Techniques for Bottom-Up Synthetic Biology.Micromachines · 2019Review
- The hallmarks of living systems: towards creating artificial cells.Interface focus · 2018Review
- Functionalizing cell-mimetic giant vesicles with encapsulated bacterial biosensors.Interface focus · 2018Article
- Mastering Complexity: Towards Bottom-up Construction of Multifunctional Eukaryotic Synthetic Cells.Trends in biotechnology · 2018Review
- Engineering thermoresponsive phase separated vesicles formedChemical science · 2018Article
- Review
- Sculpting and fusing biomimetic vesicle networks using optical tweezers.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quest to construct artificial cells from the bottom-up using simple building blocks has received much attention over recent decades and is one of the grand challenges in synthetic biology. Cell mimics that are encapsulated by lipid membranes are a particularly powerful class of artificial cells due to their biocompatibility and the ability to reconstitute biological machinery within them. One of the key obstacles in the field centres on the following: how can membrane-based artificial cells be generated in a controlled way and in high-throughput? In particular, how can they be constructed to have precisely defined parameters including size, biomolecular composition and spatial organization? Microfluidic generation strategies have proved instrumental in addressing these questions. This article will outline some of the major principles underpinning membrane-based artificial cells and their construction using microfluidics, and will detail some recent landmarks that have been achieved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.