ArticleScientific reports2016
Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Determination of moxifloxacin in milk using a ratiometric fluorescent sensor based on Ag-MOF@curcumin.RSC advances · 2024Article
- Value of multiphoton microscopy in uro-oncology: a narrative review.Translational andrology and urology · 2023Review
- Assessment of Extramammary Paget Disease by Two-Photon Microscopy.Frontiers in medicine · 2022Article
- Multimodal microscopy for the simultaneous visualization of five different imaging modalities using a single light source.Biomedical optics express · 2021Article
- Clinically Compatible Fluorescence Microscopy Based on Moxifloxacin Antibiotic.Advances in experimental medicine and biology · 2021Article
- Moxifloxacin based fluorescence imaging of intestinal goblet cells.Biomedical optics express · 2020Article
- Moxifloxacin based axially swept wide-field fluorescence microscopy for high-speed imaging of conjunctival goblet cells.Biomedical optics express · 2020Article
- High-speed combined reflectance confocal and moxifloxacin based two-photon microscopy.Biomedical optics express · 2020Article
- In vivo fluorescence imaging of conjunctival goblet cells.Scientific reports · 2019Article
- Skin Imaging Using Ultrasound Imaging, Optical Coherence Tomography, Confocal Microscopy, and Two-Photon Microscopy in Cutaneous Oncology.Frontiers in medicine · 2019Review
- Two-photon microscopy of Paneth cells in the small intestine of live mice.Scientific reports · 2018Article
- Three-photon tissue imaging using moxifloxacin.Scientific reports · 2018Article
- Visualization of laser tattoo removal treatment effects in a mouse model by two-photon microscopy.Biomedical optics express · 2017Article
- Brain tumor delineation enhanced by moxifloxacin-based two-photon/CARS combined microscopy.Biomedical optics express · 2017Article
- In Vivo Noncontact Imaging of Conjunctival Goblet Cells with Customized Widefield Fluorescence Microscopy.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 2 countries.
Funding
Abstract
Multiphoton microscopy (MPM) is a nonlinear fluorescence microscopic technique widely used for cellular imaging of thick tissues and live animals in biological studies. However, MPM application to human tissues is limited by weak endogenous fluorescence in tissue and cytotoxicity of exogenous probes. Herein, we describe the applications of moxifloxacin, an FDA-approved antibiotic, as a cell-labeling agent for MPM. Moxifloxacin has bright intrinsic multiphoton fluorescence, good tissue penetration and high intracellular concentration. MPM with moxifloxacin was demonstrated in various cell lines, and animal tissues of cornea, skin, small intestine and bladder. Clinical application is promising since imaging based on moxifloxacin labeling could be 10 times faster than imaging based on endogenous fluorescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.