Evidence map›Paper›PMID 27283789›Full record

ArticleBioorganic & medicinal chemistry2016

Piperidine-based glycodendrons as protein N-glycan prosthetics.

Jason E Hudak, Brian Belardi, Mason J Appel, Angelo Solania, Peter V Robinson, Carolyn R Bertozzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jason E HudakDepartment of Chemistry, University of California Berkeley, CA 94720, USA.
Brian BelardiDepartment of Chemistry, University of California Berkeley, CA 94720, USA.
Mason J AppelDepartment of Chemistry, University of California Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California Berkeley, CA 94720, USA.
Angelo SolaniaDepartment of Chemistry, University of California Berkeley, CA 94720, USA.
Peter V RobinsonDepartment of Chemistry, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Carolyn R BertozziDepartment of Chemistry, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: bertozzi@stanford.edu.
University of California, Berkeley · USHoward Hughes Medical Institute · US

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Investigations of Golgi EnzymesR01GM059907 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BERTOZZI, CAROLYN · 1999 to 2016
$5.9M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM059907NIGMS NIH HHS T32 GM066698
6 · The paper itself

Abstract

The generation of homogeneously glycosylated proteins is essential for defining glycoform-specific activity and improving protein-based therapeutics. We present a novel glycodendron prosthetic which can be site-selectively appended to recombinant proteins to create 'N-glycosylated' glycoprotein mimics. Using computational modeling, we designed the dendrimer scaffold and protein attachment point to resemble the native N-glycan architecture. Three piperidine-melamine glycodendrimers were synthesized via a chemoenzymatic route and attached to human growth hormone and the F

Indexed as

DendrimersHumansMolecular StructurePiperidinesPolysaccharidesProteinsTriazinesDendrimersmelaminepiperidinePiperidinesPolysaccharidesProteinsTriazinesChemoenzymatic synthesisGlycodendrimerGlycoproteinOximeProtein engineering

Identifiers

PMID27283789
PMCPMC5052108
OpenAlexW2403912037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.