ArticleInternational journal of epidemiology2017
Interrupted time series regression for the evaluation of public health interventions: a tutorial.
Article in International journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 1,767 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Informal Opinions of the Infectious Disease Specialist Referent for the Good Use of AnTiBiotics in General Medicine
Policy Responses Against the COVID-19 Pandemic in Latin America: Interrupted Series Analyses of Local Governments
TeamBirth - an Intervention to Improve Patient Safety and Person-centered Care During Childbirth
Who cites it
1,767 citing papers in PubMed.
- Impact of the two-dose varicella vaccination recommendation program and surveillance optimization on epidemiological trends in a megacity in China.Human vaccines & immunotherapeutics · 2026Article
- Impact of two-dose varicella vaccination in Guangzhou: An interrupted time-series study.Human vaccines & immunotherapeutics · 2026Article
- Impact of immunization strategies, public health and social measures on the incidence of varicella among children aged 0-14 years in Quzhou City.Human vaccines & immunotherapeutics · 2026Article
- Reducing short-acting beta-agonist overprescribing in general practice: Evaluation of a quality improvement programme in East London.The European journal of general practice · 2026Article
- Early effects of HPV vaccination on high-grade cervical intraepithelial neoplasia in Brazil: Evidence from outpatient data.Human vaccines & immunotherapeutics · 2026Article
- Did the COVID-19 pandemic impact on time trends in self-poisoning in youth? A sex-specific national register-based interrupted time-series analysis in Sweden.The British journal of clinical psychology · 2026Article
- Sustained Benefits of a Multidomain Lifestyle Intervention in Multiple Sclerosis in the LIMS Study: A 24-Month Follow-Up.Neurology · 2026Observational
- COVID-19 pandemic-era changes in non-SUID infant mortality in the United States.BMJ paediatrics open · 2026Article
- Has the COVID-19 pandemic altered social inequalities in child development? A time trend analysis of developmental delays in preschool children by parental education.Archives of public health = Archives belges de sante publique · 2026Article
- National trends in infection-related mortality among US cancer decedents in the immunotherapy era (1999-2023).Medicine · 2026Article
- Real-Time Physical Activity Self-Monitoring in Patients Hospitalized for Cardiology Care: Interrupted Time Series Analysis.JMIR cardio · 2026Article
- 10 Years of BRAVE Self-Help Service Delivery for Child and Adolescent Anxiety in Australia: Open Effectiveness-Implementation Trial.Journal of medical Internet research · 2026Article
- Impact of the COVID-19 Pandemic on Treatment Outcomes and Healthcare Utilization Among People Living With HIV in Korea: A Multicenter Cohort Study.Journal of Korean medical science · 2026Observational
- Interpreting Policy Effects on Multidisciplinary Kidney Care: Autoregressive Integrated Moving Average Diagnostics and the Late Referral Denominator.Journal of the American Society of Nephrology : JASN · 2026Article
- Regulatory Policy Changes and Mifepristone Access Through Pharmacies in Australia.JAMA network open · 2026Article
- Collaborative pharmacist prescribing in community heart failure clinics: a pre-post intervention comparison.International journal of clinical pharmacy · 2026Observational
- Clinical Decision Support to Reduce Opioid Prescribing at Discharge for Inpatients Undergoing Surgery (LESS Study): An Interrupted Time Series Analysis.Anesthesiology · 2026Article
- The Impact of Hurricane Harvey on Home Health Care Delivery for Medicare Beneficiaries.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- A quasi-experimental study of abortion rates following gestational age limit changes in Japan.Nature human behaviour · 2026Article
- Trends in annual medication possession in older adults with type 2 diabetes.Journal of managed care & specialty pharmacy · 2026Article
1,707 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Interrupted time series (ITS) analysis is a valuable study design for evaluating the effectiveness of population-level health interventions that have been implemented at a clearly defined point in time. It is increasingly being used to evaluate the effectiveness of interventions ranging from clinical therapy to national public health legislation. Whereas the design shares many properties of regression-based approaches in other epidemiological studies, there are a range of unique features of time series data that require additional methodological considerations. In this tutorial we use a worked example to demonstrate a robust approach to ITS analysis using segmented regression. We begin by describing the design and considering when ITS is an appropriate design choice. We then discuss the essential, yet often omitted, step of proposing the impact model a priori. Subsequently, we demonstrate the approach to statistical analysis including the main segmented regression model. Finally we describe the main methodological issues associated with ITS analysis: over-dispersion of time series data, autocorrelation, adjusting for seasonal trends and controlling for time-varying confounders, and we also outline some of the more complex design adaptations that can be used to strengthen the basic ITS design.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.