ArticleEcoHealth2016
Water Temperature Affects Susceptibility to Ranavirus.
Article in EcoHealth, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Excess mortality of infected ectotherms induced by warming depends on pathogen kingdom and evolutionary history.PLoS biology · 2024Pooled it
- Article
- Experimental evidence for behavioural cooling as a response to virus infection in an ectothermic vertebrate.BMC biology · 2026Article
- The Individual and Combined Effects of Warming and Atrazine on Lithobates pipiens Phenotypes: Implications for Frog Declines.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Identification of Simultaneous Occurrence of Amphibian Chytrid Fungi and Ranavirus in South Korea.Animals : an open access journal from MDPI · 2025Article
- Temperature and Resources Interact to Affect Transmission via Host Foraging Rate and Susceptibility.Ecology letters · 2025Article
- Continent-Wide Distribution of CMTV-Like Ranavirus, from the Urals to the Atlantic Ocean.EcoHealth · 2025Article
- Testing the Population-Level Effects of Stress-Induced Susceptibility in the Ranavirus-Wood Frog System.Ecology and evolution · 2025Article
- Heat stress and amphibian immunity in a time of climate change.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Experimental evidence that host species composition alters host-pathogen dynamics in a ranavirus-amphibian assemblage.Ecology · 2023Article
- Influence of Herbicide Exposure and Ranavirus Infection on Growth and Survival of Juvenile Red-Eared Slider Turtles (Viruses · 2021Article
- Article
- Chiggers (Acariformes: Trombiculoidea) do not increase rates of infection byInternational journal for parasitology. Parasites and wildlife · 2020Article
- Article
- Behavioural fever reduces ranaviral infection in toads.Functional ecology · 2019Article
- Article
- Functional variation at an expressed MHC class IIβ locus associates with Ranavirus infection intensity in larval anuran populations.Immunogenetics · 2019Article
- Article
- Seasonal dynamics and potential drivers of ranavirus epidemics in wood frog populations.Oecologia · 2018Article
- Water Contaminants Associated With Unconventional Oil and Gas Extraction Cause Immunotoxicity to Amphibian Tadpoles.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The occurrence of emerging infectious diseases in wildlife populations is increasing, and changes in environmental conditions have been hypothesized as a potential driver. For example, warmer ambient temperatures might favor pathogens by providing more ideal conditions for propagation or by stressing hosts. Our objective was to determine if water temperature played a role in the pathogenicity of an emerging pathogen (ranavirus) that infects ectothermic vertebrate species. We exposed larvae of four amphibian species to a Frog Virus 3 (FV3)-like ranavirus at two temperatures (10 and 25°C). We found that FV3 copies in tissues and mortality due to ranaviral disease were greater at 25°C than at 10°C for all species. In a second experiment with wood frogs (Lithobates sylvaticus), we found that a 2°C change (10 vs. 12°C) affected ranaviral disease outcomes, with greater infection and mortality at 12°C. There was evidence that 10°C stressed Cope's gray tree frog (Hyla chrysoscelis) larvae, which is a species that breeds during summer-all individuals died at this temperature, but only 10% tested positive for FV3 infection. The greater pathogenicity of FV3 at 25°C might be related to faster viral replication, which in vitro studies have reported previously. Colder temperatures also may decrease systemic infection by reducing blood circulation and the proportion of phagocytes, which are known to disseminate FV3 through the body. Collectively, our results indicate that water temperature during larval development may play a role in the emergence of ranaviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.