Evidence map›Paper›PMID 27282910›Full record

ReviewCancer medicine2016

MicroRNAs in glioblastoma multiforme pathogenesis and therapeutics.

Amanda Shea, Varsha Harish, Zainab Afzal, Juliet Chijioke, Habib Kedir, Shahnoza Dusmatova, Arpita Roy, Malathi Ramalinga, Brent Harris, Jan Blancato and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 1 synthesis or guideline pooled it, 207 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Review
  6. Article
  7. Review
  8. Review
  9. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  10. Article
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  12. Article
  13. Article
  14. Review
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  17. Article
  18. Review
  19. Review
  20. Regulation of autophagy by non-coding RNAs in human glioblastoma.Medical oncology (Northwood, London, England) · 2024
    Review

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Amanda SheaDivision of Science and Mathematics, Cancer Research Laboratory, University of the District of Columbia, Washington, District of Columbia, 20008.
Varsha HarishGroton School, Groton, Massachusetts, 01450.
Zainab AfzalDivision of Science and Mathematics, Cancer Research Laboratory, University of the District of Columbia, Washington, District of Columbia, 20008.
Juliet ChijiokeDivision of Science and Mathematics, Cancer Research Laboratory, University of the District of Columbia, Washington, District of Columbia, 20008.
Habib KedirDivision of Science and Mathematics, Cancer Research Laboratory, University of the District of Columbia, Washington, District of Columbia, 20008.
Shahnoza DusmatovaDivision of Science and Mathematics, Cancer Research Laboratory, University of the District of Columbia, Washington, District of Columbia, 20008.
Arpita RoyDivision of Science and Mathematics, Cancer Research Laboratory, University of the District of Columbia, Washington, District of Columbia, 20008.
Malathi RamalingaDivision of Science and Mathematics, Cancer Research Laboratory, University of the District of Columbia, Washington, District of Columbia, 20008.
Brent HarrisDepartment of Neurology and Pathology, Georgetown University, Washington, District of Columbia, 20057.
Jan BlancatoLombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, 20057.
Mukesh VermaDivision of Cancer Control and Population Sciences, National Cancer Institute (NCI), National Institutes of Health (NIH), Rockville, Maryland, 20850.
Deepak KumarDivision of Science and Mathematics, Cancer Research Laboratory, University of the District of Columbia, Washington, District of Columbia, 20008.
University of the District of Columbia · USGeorgetown University · USApplied Physical Sciences (United States) · USNational Institutes of Health · US

Funding

MicroRNAs in African American Prostate CancerU01CA194730 · NCI · UNIVERSITY OF THE DISTRICT OF COLUMBIA · PI KUMAR, DEEPAK · 2015 to 2020
$1.8M
NCI NIH HHS U01 CA194730
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain, remaining incurable with a median survival time of only 15 months. In an effort to identify new targets for GBM diagnostics and therapeutics, recent studies have focused on molecular phenotyping of GBM subtypes. This has resulted in mounting interest in microRNAs (miRNAs) due to their regulatory capacities in both normal development and in pathological conditions such as cancer. miRNAs have a wide range of targets, allowing them to modulate many pathways critical to cancer progression, including proliferation, cell death, metastasis, angiogenesis, and drug resistance. This review explores our current understanding of miRNAs that are differentially modulated and pathologically involved in GBM as well as the current state of miRNA-based therapeutics. As the role of miRNAs in GBM becomes more well understood and novel delivery methods are developed and optimized, miRNA-based therapies could provide a critical step forward in cancer treatment.

Indexed as

Genetic TherapyAnimalsBrain NeoplasmsGene Expression Regulation, NeoplasticGlioblastomaHumansMicroRNAsRNA InterferenceMicroRNAscancer therapyglioblastoma multiformemicroRNA

Identifiers

PMID27282910
PMCPMC4971921
OpenAlexW2415253563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.