Evidence map›Paper›PMID 27282805›Full record

ArticleScientific reports2016

Mechanisms of PDGF siRNA-mediated inhibition of bone cancer pain in the spinal cord.

Yang Xu, Jia Liu, Mu He, Ran Liu, Visar Belegu, Ping Dai, Wei Liu, Wei Wang, Qing-Jie Xia, Fei-Fei Shang and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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  12. RNA control in pain: Blame it on the messenger.Wiley interdisciplinary reviews. RNA · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Yang XuInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Jia LiuInstitute of Neuroscience, Kunming Medical University, Kunming 650031, PR China.
Mu HeDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Ran LiuInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Visar BeleguDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA, International Center for Spinal Cord Injury, Hugo W. Moser Research Institute at Kennedy Krieger Inc., Baltimore, MD, USA.
Ping DaiDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Wei LiuInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Wei WangInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Qing-Jie XiaInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Fei-Fei ShangInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Chao-Zhi LuoInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Xue ZhouDepartment of Histology, Embryology and Neurobiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China.
Su LiuDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA, International Center for Spinal Cord Injury, Hugo W. Moser Research Institute at Kennedy Krieger Inc., Baltimore, MD, USA.
JohnW McDonaldDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA, International Center for Spinal Cord Injury, Hugo W. Moser Research Institute at Kennedy Krieger Inc., Baltimore, MD, USA.
Jin LiuInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Yun-Xia ZuoInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Fei LiuInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Ting-Hua WangInstitute of Neurological Disease, Department of Anesthesiology and Translation Neuroscience Center, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Sichuan University · CNWest China Hospital of Sichuan University · CNKunming Medical University · CNKennedy Krieger Institute · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with tumors that metastasize to bone frequently suffer from debilitating pain, and effective therapies for treating bone cancer are lacking. This study employed a novel strategy in which herpes simplex virus (HSV) carrying a small interfering RNA (siRNA) targeting platelet-derived growth factor (PDGF) was used to alleviate bone cancer pain. HSV carrying PDGF siRNA was established and intrathecally injected into the cavum subarachnoidale of animals suffering from bone cancer pain and animals in the negative group. Sensory function was assessed by measuring thermal and mechanical hyperalgesia. The mechanism by which PDGF regulates pain was also investigated by comparing the differential expression of pPDGFRα/β and phosphorylated ERK and AKT. Thermal and mechanical hyperalgesia developed in the rats with bone cancer pain, and these effects were accompanied by bone destruction in the tibia. Intrathecal injection of PDGF siRNA and morphine reversed thermal and mechanical hyperalgesia in rats with bone cancer pain. In addition, we observed attenuated astrocyte hypertrophy, down-regulated pPDGFRα/β levels, reduced levels of the neurochemical SP, a reduction in CGRP fibers and changes in pERK/ERK and pAKT/AKT ratios. These results demonstrate that PDGF siRNA can effectively treat pain induced by bone cancer by blocking the AKT-ERK signaling pathway.

Indexed as

AnimalsAstrocytesBone NeoplasmsCancer PainDown-RegulationFemaleHyperalgesiaMorphinePlatelet-Derived Growth FactorRatsRats, Sprague-DawleyReceptors, Platelet-Derived Growth FactorRNA, Small InterferingSignal TransductionSimplexvirusSpinal CordMorphinePlatelet-Derived Growth FactorReceptors, Platelet-Derived Growth FactorRNA, Small Interfering

Identifiers

PMID27282805
PMCPMC4901320
OpenAlexW2408756973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.