ReviewJournal of musculoskeletal & neuronal interactions2016
Centrifugation as a countermeasure during bed rest and dry immersion: What has been learned?
Review in Journal of musculoskeletal & neuronal interactions, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Limited musculoskeletal benefits of artificial gravity combined with cycling during bed rest: Results from the BRACE study.Experimental physiology · 2026Trial
- Daily 30-min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT.European journal of applied physiology · 2021Trial
- Medial gastrocnemius activation during graded axial hypergravity induced by short-arm human centrifugation.European journal of applied physiology · 2026Article
- The effect of artificial gravity on the outcome of a two-week resistance vibration exercise programme: BRAVE study.Experimental physiology · 2026Article
- Fluid shifts are main drivers for microgravity simulation-induced immune-physiological changes: findings from the VIVALDI studies.NPJ microgravity · 2026Article
- Reduced postural stability in men and women aged 55-65 following 14 days of head-down bed rest.Scientific reports · 2025Article
- Comparison of joint kinematics between upright front squat exercise and horizontal squat exercise performed on a short arm human centrifugation.Physiological reports · 2024Article
- Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation.Nature communications · 2023Article
- Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Article
- Impact of different ground-based microgravity models on human sensorimotor system.Frontiers in physiology · 2023Review
- Comparison of trunk muscle exercises in supine position during short arm centrifugation with 1 g at centre of mass and upright in 1 g.Frontiers in physiology · 2022Article
- Assessing the effects of artificial gravity in an analog of long-duration spaceflight: The protocol and implementation of the AGBRESA bed rest study.Frontiers in physiology · 2022Article
- Effects of Various Muscle Disuse States and Countermeasures on Muscle Molecular Signaling.International journal of molecular sciences · 2021Review
- Adaptability of a jump movement pattern to a non-constant force field elicited via centrifugation.PloS one · 2020Article
- Effects of centrifugation and whole-body vibrations on blood-brain barrier permeability in mice.NPJ microgravity · 2020Article
- Tolerability of daily intermittent or continuous short-arm centrifugation during 60-day 6o head down bed rest (AGBRESA study).PloS one · 2020Article
- Artificial Gravity as a Countermeasure to the Cardiovascular Deconditioning of Spaceflight: Gender Perspectives.Frontiers in physiology · 2018Review
- Galanin and Adrenomedullin Plasma Responses During Artificial Gravity on a Human Short-Arm Centrifuge.Frontiers in physiology · 2018Article
- A Comparison of Squatting Exercise on a Centrifuge and With Earth Gravity.Frontiers in physiology · 2018Article
- Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise.Frontiers in physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe review the studies that have evaluated intermittent short-radius centrifugation as a potential countermeasure for cardiovascular, musculoskeletal, and sensorimotor deconditioning in simulated weightlessness.
methodsThe findings from 18 experimental protocols that have used bed rest and dry immersion for comparing the protective effects of centrifugation versus standing upright or walking, and the effects of continuous vs. periodic exposure to centrifugation are discussed.
resultsCentrifugation for as little as 30 min per day was found to be effective in mitigating orthostatic intolerance and strength in postural muscle after 5 days of bed rest, but it was not effective in mitigating plasma volume loss.
conclusionTo determine the optimal prescription for centrifugation as a countermeasure, we recommend further studies using (a) bed rest of longer duration, (b) individualized prescriptions of centrifugation combined with exercise, and
Indexed as
Identifiers
27282452PMC5114351What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.