ArticleeLife2016
Anatomical organization of presubicular head-direction circuits.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 85 citations in OpenAlex.
- Protocol for identifying head direction cells in mice using in vivo extracellular recordings and juxtacellular labeling.STAR protocols · 2026Article
- Article
- Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Aversion Encoding and Behavioral State Modulation of Physiologically Defined Cell Types in the Lateral Habenula.The European journal of neuroscience · 2025Article
- Comparison of head direction cell firing characteristics across thalamo-parahippocampal circuitry.Hippocampus · 2024Article
- Unsupervised classification of brain-wide axons reveals the presubiculum neuronal projection blueprint.Nature communications · 2024Article
- Unsupervised classification of brain-wide axons reveals neuronal projection blueprint.Research square · 2023Article
- cFOS as a biomarker of activity maturation in the hippocampal formation.Frontiers in neuroscience · 2023Article
- Attractor-like Dynamics in the Subicular Complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Sharp Tuning of Head Direction and Angular Head Velocity Cells in the Somatosensory Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Angular and linear speed cells in the parahippocampal circuits.Nature communications · 2022Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
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- Article
- Mapping vestibular and visual contributions to angular head velocity tuning in the cortex.Cell reports · 2021Article
- Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function.Neuropsychology review · 2021Review
- Article
- Spatially structured inhibition defined by polarized parvalbumin interneuron axons promotes head direction tuning.Science advances · 2021Article
- Molecular Characterization of Superficial Layers of the Presubiculum During Development.Frontiers in neuroanatomy · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons coding for head-direction are crucial for spatial navigation. Here we explored the cellular basis of head-direction coding in the rat dorsal presubiculum (PreS). We found that layer2 is composed of two principal cell populations (calbindin-positive and calbindin-negative neurons) which targeted the contralateral PreS and retrosplenial cortex, respectively. Layer3 pyramidal neurons projected to the medial entorhinal cortex (MEC). By juxtacellularly recording PreS neurons in awake rats during passive-rotation, we found that head-direction responses were preferentially contributed by layer3 pyramidal cells, whose long-range axons branched within layer3 of the MEC. In contrast, layer2 neurons displayed distinct spike-shapes, were not modulated by head-direction but rhythmically-entrained by theta-oscillations. Fast-spiking interneurons showed only weak directionality and theta-rhythmicity, but were significantly modulated by angular velocity. Our data thus indicate that PreS neurons differentially contribute to head-direction coding, and point to a cell-type- and layer-specific routing of directional and non-directional information to downstream cortical targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.