ArticleInternational journal of geriatric psychiatry2017
Immunological biomarkers associated with brain structure and executive function in late-life depression: exploratory pilot study.
Article in International journal of geriatric psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The relationship between immune and cognitive dysfunction in mood and psychotic disorder: a systematic review and a meta-analysis.Molecular psychiatry · 2022Pooled it
- Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review.International journal of molecular sciences · 2016Pooled it
- Longitudinal Changes in White Matter Hypointensities in Recurrent Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research.Translational psychiatry · 2022Review
- How Inflammation Affects the Brain in Depression: A Review of Functional and Structural MRI Studies.Journal of clinical neurology (Seoul, Korea) · 2021Review
- Serum Cytokine Profile, Beta-Hexosaminidase A Enzymatic Activity and GMLife (Basel, Switzerland) · 2021Article
- Preliminary Evidence for a Relationship between Elevated Plasma TNFα and Smaller Subcortical White Matter Volume in HCV Infection Irrespective of HIV or AUD Comorbidity.International journal of molecular sciences · 2021Article
- Subjective Sleep Quality and Trajectories of Interleukin-6 in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
- TNF-α and its soluble receptors mediate the relationship between prior severe mood episodes and cognitive dysfunction in euthymic bipolar disorder.Brain, behavior, and immunity · 2020Article
- Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Review
- Mechanisms and treatment of late-life depression.Translational psychiatry · 2019Review
- Does the MIND diet decrease depression risk? A comparison with Mediterranean diet in the SUN cohort.European journal of nutrition · 2019Article
- Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers.Metabolic brain disease · 2019Article
- Depressive Symptoms Are Associated with Cognitive Function in the Elderly with Type 2 Diabetes.Journal of Alzheimer's disease : JAD · 2018Article
- Gray matter regions statistically mediating the cross-sectional association of eotaxin and set-shifting among older adults with major depressive disorder.International journal of geriatric psychiatry · 2017Article
- Association between change in brain gray matter volume, cognition, and depression severity: Pre- and post- antidepressant pharmacotherapy for late-life depression.Journal of psychiatric research · 2017Article
- Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study.Scientific reports · 2017Article
- Inflammation in Schizophrenia: Cytokine Levels and Their Relationships to Demographic and Clinical Variables.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Plasma IL-17A levels in patients with late-life depression.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveSeveral immunological biomarkers are altered in late-life major depressive disorder (LLD). Immunological alterations could contribute to LLD's consequences, but little is known about the relations between specific immunological biomarkers and brain health in LLD. We performed an exploratory pilot study to identify, from several candidates, the specific immunological biomarkers related to important aspects of brain health that are altered in LLD (brain structure and executive function).
methodsAdults (n = 31) were at least 60 years old and had major depressive disorder. A multiplex immunoassay assessed 13 immunological biomarkers, and we examined their associations with structural MRI (grey matter volume and white matter hyperintensity volume (WMH)) and executive function (Color-Word Interference and Trail-Making tests) measures.
resultsVascular endothelial growth factor (VEGF) and the chemokine eotaxin had significant negative associations with grey matter volume (VEGF: n = 31, r = -0.65; eotaxin: n = 29, r = -0.44). Tumor necrosis factor alpha (TNF-α) had a significant positive relationship with WMHs (n = 30, r = 0.52); interferon-γ (IFN-γ) and macrophage inflammatory protein-1α (MIP-1α) were also significantly associated with WMHs (IFN-γ: n = 31, r = 0.48; MIP-1α: n = 29, r = 0.45). Only eotaxin was associated with executive function (set-shifting performance as measured with the Trail-making test: n = 33, r = -0.43).
conclusionsImmunological markers are associated with brain structure in LLD. We found the immunological correlates of grey and white matter differ. Prospective studies are needed to evaluate whether these immunological correlates of brain health increase the risk of LLD's consequences. Eotaxin, which correlated with both grey matter volume and set-shifting performance, may be particularly relevant to neurodegeneration and cognition in LLD. Copyright © 2016 John Wiley & Sons, Ltd.
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