ReviewNeuroscience2017
The neural underpinnings of cognitive flexibility and their disruption in psychotic illness.
Review in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The role of cue transparency in task switching: an SDM-PSI meta-analysis in healthy adults.Brain imaging and behavior · 2026Pooled it
- Population-Level Age Effects on the White Matter Structure Subserving Cognitive Flexibility in the Human Brain.eNeuro · 2026Pooled it
- Treatment effect modifiers of virtual reality-based versus standard cognitive behavioral therapy for paranoia in schizophrenia spectrum disorders: an exploratory moderator analysis of clinical and demographic characteristics in the FaceYourFears trial.Psychological medicine · 2026Trial
- The GPR139 agonist TAK-041 produces time-dependent alterations to cerebral blood flow and reward system function in patients with schizophrenia: a randomised placebo-controlled trial.Psychopharmacology · 2026Trial
- L-DOPA administration shifts the stability-flexibility balance towards attentional capture by distractors during a visual search task.Psychopharmacology · 2022Trial
- Preliminary evidence for the phosphodiesterase type-4 inhibitor, roflumilast, in ameliorating cognitive flexibility deficits in patients with schizophrenia.Journal of psychopharmacology (Oxford, England) · 2021Trial
- Dopamine depletion effects on cognitive flexibility as modulated by tDCS of the dlPFC.Brain stimulationTrial
- Chemogenetic inhibition of the ventrolateral orbitofrontal cortex disrupts novelty-guided updating of spatial memories and alters hippocampal engram reactivation.Psychopharmacology · 2026Article
- Implementing Point-of-Care Fingerstick Testing for Clozapine Safety Monitoring in Outpatient Psychiatry: A Convergent Mixed Methods Study.Community mental health journal · 2026Article
- Examining clinical relevance of interpretation inflexibility in social contexts.Annals of general psychiatry · 2026Article
- The development of FEDUPP: feeding experimentation device users processing package to assess learning and cognitive flexibility.Translational psychiatry · 2026Article
- Flexible brain state engagement predicts cognitive control transdiagnostically.bioRxiv : the preprint server for biology · 2026Article
- Relating latent factors of reasoning, affect, and cognition to the delusional experience.Schizophrenia (Heidelberg, Germany) · 2026Article
- Advancing Understanding of Treatment Response in Schizophrenia With Psychosis Using a Novel Dynamic Reward Task.Schizophrenia bulletin · 2026Article
- Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025.Molecular brain · 2026Review
- Belief inflexibility reduces the impact of allostatic overload on psychotic-like experiences among Ukrainian refugees.Frontiers in psychiatry · 2026Article
- Dynamic Interplay between Prefrontal Theta and Beta Bursts Facilitates Flexible Learning.Experimental neurobiology · 2025Article
- Thalamic regulation of reinforcement learning strategies across prefrontal-striatal networks.Nature communications · 2025Article
- The neural basis for uncertainty processing in hierarchical decision making.Nature communications · 2025Article
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Schizophrenia (SZ) has long been associated with a variety of cognitive deficits, including reduced cognitive flexibility. More recent findings, however, point to tremendous inter-individual variability among patients on measures of cognitive flexibility/set-shifting. With an eye toward shedding light on potential sources of variability in set-shifting abilities among SZ patients, I examine the neural substrates of underlying probabilistic reversal learning (PRL) - a paradigmatic measure of cognitive flexibility - as well as neuromodulatory influences upon these systems. Finally, I report on behavioral and neuroimaging studies of PRL in SZ patients, discussing the potentially influences of illness profile and antipsychotic medications on cognitive flexibility in SZ.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.