Evidence map›Paper›PMID 27281308›Full record

Trial reportThe American journal of clinical nutrition2016

Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

Tao Huang, Sylvia H Ley, Yan Zheng, Tiange Wang, George A Bray, Frank M Sacks, Lu Qi

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00072995 (Preventing Overweight Using Novel Dietary Strategies), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00072995 nacompletednot on this map

Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)

TypeinterventionalSponsorBrigham and Women's HospitalRan2003 to 2007Enrolled811ConditionsCardiovascular Diseases, Heart Diseases, ObesityArmsFour Diets Differing in Macronutrient Composition, Diets Low in Saturated Fat
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes.Frontiers in bioengineering and biotechnology · 2020
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Tao HuangDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA; Epidemiology Domain, Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;
Sylvia H LeyDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA;
Yan ZhengDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA;
Tiange WangDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA;
George A BrayPennington Biomedical Research Center of the Louisiana State University System, Baton Rouge, LA; and.
Frank M SacksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA;
Lu QiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA nhlqi@channing.harvard.edu.
Harvard University · USTulane University · USPennington Biomedical Research Center · US

Funding

Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut MicrobiotaR01DK100383 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2014 to 2024
$4.2M
Genome-wide interactions with diet patterns on long-term weight changeR21HL126024 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2015 to 2016
$421k
NHLBI NIH HHS R21 HL126024NIDDK NIH HHS R01 DK100383
6 · The paper itself

Abstract

backgroundDiet interventions have shown effectiveness in improving diabetes risk factors; however, little is known about whether the effects of diet intervention are different according to genetic susceptibility.

objectiveWe examined interactions between weight-loss diets and the genetic risk score (GRS) for diabetes on 2-y changes in markers of insulin resistance and β cell function in a randomized controlled trial.

designData from the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial were analyzed. A GRS was calculated on the basis of 31 diabetes-associated variants in 744 overweight or obese nondiabetic adults (80% white Americans). We assessed the changes in insulin resistance and β cell function over the 2-y intervention.

resultsDietary protein significantly interacted with the diabetes GRS on fasting insulin, glycated hemoglobin (HbA1c), the homeostasis model assessment of β cell function (HOMA-B), and the homeostasis model assessment of insulin resistance (HOMA-IR) at 2 y in white Americans (P-interaction = 0.02, 0.04, 0.01, and 0.05, respectively). The lower GRS was associated with a greater decrease in fasting insulin (P = 0.04), HbA1c (P = 0.0001), and HOMA-IR (P = 0.02), and a lesser increase in HOMA-B (P = 0.004) in participants consuming a low-protein diet. Participants with a higher GRS might have a greater reduction in fasting insulin when consuming a high-protein diet (P = 0.03).

conclusionsOur data suggest that individuals with a lower genetic risk of diabetes may benefit more from consuming a low-protein weight-loss diet in improving insulin resistance and β cell function, whereas a high-protein diet may be more beneficial for white patients with a higher genetic risk. This trial was registered at clinicaltrials.gov as NCT00072995.

Indexed as

Diabetes MellitusGenetic VariationAdultBlood GlucoseDietary ProteinsDiet, ReducingFastingFemaleGenetic Predisposition to DiseaseGenotypeGlycated HemoglobinHumansInsulinInsulin ResistanceInsulin-Secreting CellsMaleBlood GlucoseDietary ProteinsGlycated HemoglobinInsulingene–diet interactiongenetic risk scoreinsulin resistanceweight-loss dietsβ cell function

Identifiers

PMID27281308
PMCPMC4919524
OpenAlexW2414314476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.