ArticlePloS one2016
Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Diagnosis and Treatment of Local Allergic Rhinitis.Pathogens (Basel, Switzerland) · 2022Review
- Local Respiratory Allergy: From Rhinitis Phenotype to Disease Spectrum.Frontiers in immunology · 2021Review
- Serum and local IL-4, IL-5, IL-13 and immunoglobulin E in allergic rhinitis.Postepy dermatologii i alergologii · 2020Article
- Nasal specific IgE to Der p is not an acceptable screening test to predict the outcome of the nasal challenge test in patients with non-allergic rhinitis.The World Allergy Organization journal · 2020Article
- Local Allergic Rhinitis Revisited.Current allergy and asthma reports · 2020Review
- Feasibility of flow cytometry in the rhinologist's clinic.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2020Article
- Inflammation, infection, and allergy of upper airways: new insights from national and real-world studies.Italian journal of pediatrics · 2020Article
- How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians.Journal of clinical medicine · 2019Review
- International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.International forum of allergy & rhinology · 2018Article
- The role of local allergy in the nasal inflammation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Review
- miR-371, miR-138, miR-544, miR-145, and miR-214 could modulate Th1/Th2 balance in asthma through the combinatorial regulation of Runx3.American journal of translational research · 2017Article
- Local allergic rhinitis: entopy or spontaneous response?The World Allergy Organization journal · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAllergic rhinitis (AR) is the most common allergic disease but little is known about the difference of local immune responses in children and adults with AR.
objectiveTo compare local immune responses between children and adults with AR and nonallergic rhinitis (NAR), and to investigate whether the association of local and systemic immune responses is different between the two age groups.
methodsFifty-one patients with chronic rhinitis were enrolled and grouped into children (N = 27, mean age 7.2 years) and adults (N = 24, mean age 29.9 years). Diagnosis of AR was based on symptoms, skin prick tests and serum specific IgEs. Nasal lavage (NAL) fluids were collected from all subjects and used to measure the levels of total IgE, specific IgEs to house dust mites (Dp and Df), and cytokines (TNF-α, IL-4, IL-10, IL-17A and IFN-γ). Flow cytometry was used to measure inflammatory cell types in NAL fluids.
resultsAR had significantly increased local levels of total IgE and specific IgEs to Dp and Df compared with NAR in both age groups (P < 0.05). Nasal eosinophils % (P = 0.01) was significantly increased only in children with AR. Local-systemic correlations of total IgE (r = 0.662, P = 0.000) and eosinophil % (r = 0.461, P = 0.015) between the peripheral blood and NAL fluids were found only in children. Moreover, children had correlations between total IgE and eosinophil % in the peripheral blood (r = 0.629, P = 0.001) and in NAL fluids (r = 0.373, P = 0.061).
conclusionElevated local IgE is a common feature of AR in children and adults. Local measures in NAR showed naïve state of immune response which disagree with the hypothesis of local allergic rhinitis. Children showed intense local inflammation and close local-systemic interactions compared to adults supporting pediatric AR as a distinct feature.
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