Trial reportMedicine2016
Correlation of platelets count with endoscopic findings in a cohort of Egyptian patients with liver cirrhosis.
Trial report in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Platelet count, spleen length, and platelet count-to-spleen length ratio for the diagnosis of oesophageal varices in people with chronic liver disease or portal vein thrombosis.The Cochrane database of systematic reviews · 2017Pooled it
- Predictive value of platelet counts to detect grade of esophageal varices in liver cirrhosis.Journal of family medicine and primary care · 2025Article
- Poor Abilities of Noninvasive Biomarkers to Assess Esophagogastric Varices and Portal Hypertensive Gastropathy.Biomarker insights · 2025Article
- Impact of thrombocytopenia on failure of endoscopic variceal treatment in cirrhotic patients with acute variceal bleeding.Therapeutic advances in gastroenterology · 2025Article
- [An analysis of related factors in thrombocytopenia combined with cirrhosis: a cross-sectional study of 2 517 cases].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Article
- Evaluation of Noninvasive Tools for Predicting Esophageal Varices in Patients With Cirrhosis at Tygerberg Hospital, Cape Town.International journal of hepatology · 2024Article
- Derivation of "Egyptian varices prediction (EVP) index": A novel noninvasive index for diagnosing esophageal varices in HCV Patients.Journal of advanced research · 2022Article
- Clinical characteristics and risk factors of patients with flupirtine-induced liver cirrhosis complicated with upper gastrointestinal bleeding.American journal of translational research · 2021Article
- Platelet count can predict the grade of esophageal varices in cirrhotic patients: a cross-sectional study.F1000Research · 2021Article
- Article
- Fibrosis index predicts variceal bleeding and reduces need for nonselective beta-blocker in compensated cirrhosis with initial small esophageal varices without red-color sign.Annals of translational medicine · 2020Article
- Second urgent endoscopy within 48-hour benefits cirrhosis patients with acute esophageal variceal bleeding.Medicine · 2020Observational
- Validation of Revised Baveno VI Criteria for Screening of Varices Needing Treatment in Children with Cirrhosis.Clinical and experimental gastroenterology · 2020Article
- Propranolol plus endoscopic ligation for variceal bleeding in patients with significant ascites: Propensity score matching analysis.Medicine · 2020Article
- External validation of Liaoning score for predicting esophageal varices in liver cirrhosis: a Chinese multicenter cross-sectional study.Annals of translational medicine · 2019Article
- Article
- Predictors for eltrombopag response in patients with hepatitis C virus-associated thrombocytopenia.Therapeutics and clinical risk management · 2019Article
- Predictors of in-hospital mortality in a cohort of elderly Egyptian patients with acute upper gastrointestinal bleeding.Medicine · 2018Observational
- Blood Ammonia Level Correlates with Severity of Cirrhotic Portal Hypertensive Gastropathy.Gastroenterology research and practice · 2018Article
- A novel scoring system for prediction of esophageal varices in critically ill patients.Clinical and experimental gastroenterology · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Screening endoscopy is recommended for early detection of esophageal varices (EVs) in cirrhotic patients with portal hypertension. However, this approach is limited by its invasiveness and cost. The aim of the study was to determine if platelet count can predict the presence of EVs, especially large (grade III, IV) EVs in need of prophylactic therapy, in a cohort of Egyptian patients with liver cirrhosis. In all, 110 patients with cirrhosis were prospectively analyzed. The presence of medium or large EVs was correlated with patients' platelet count and FIB-4. Esophageal varices were present in 87 (79.09%) patients. Among those with thrombocytopenia (platelet level below 150,000), 25.97% (20 patients) and 27.27% (21 patients) had EV grade II and EV grade III or IV, respectively. Whereas in patients in whom the platelet count was above 150,000, only 21.21% (7 patients) and 9.09% (3 patients) of patients had grade II EV and EV grade III or IV, respectively. A platelet count cut-off value of 149,000 was found to have specificity of 82% and sensitivity 39% for detection of presence of varices. A FIB-4 cut-off value of 3.175 was found to have an 83.3% sensitivity and 39.5% specificity in detecting large (grade III, IV) EVs. Platelet count is a noninvasive parameter with high accuracy for prediction of EVs. Cirrhotic patients with normal platelet counts (above 150,000), especially in financially deprived developing countries, can avoid screening endoscopy as they are at a low risk for variceal bleeding, and presence of large EVs in these patients is much less common than in those with thrombocytopenia. A 3.175 cut-off value of FIB-4 could be useful as a noninvasive predictor of large varices requiring prophylactic banding in cirrhotic patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.