ArticleJournal of affective disorders2016
Reversal-learning deficits in childhood-onset bipolar disorder across the transition from childhood to young adulthood.
Article in Journal of affective disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Neuropsychological Development of Cool and Hot Executive Functions Between 6 and 12 Years of Age: A Systematic Review.Frontiers in psychology · 2021Pooled it
- Feature interference underlies a neuronal basis for the behavioral cost of task uncertainty.Nature neuroscience · 2026Article
- Reinforcement learning impairment in individuals with euthymic bipolar I disorder with a history of psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Computational modeling of reversal learning impairments in schizophrenia and bipolar disorder reveals shared failure to exploit rewards.Journal of psychopathology and clinical science · 2025Article
- A Novel Battery to Assess "Cool" and "Hot" Executive Functions: Sensitivity to Age Differences in Middle Childhood.Brain sciences · 2024Article
- Task interference as a neuronal basis for the cost of cognitive flexibility.bioRxiv : the preprint server for biology · 2024Article
- CaFrontiers in cellular neuroscience · 2023Article
- Cognitive Flexibility and Impulsivity Deficits in Suicidal Adolescents.Research on child and adolescent psychopathology · 2022Article
- Relationship between cognitive flexibility and subsequent course of mood symptoms and suicidal ideation in young adults with childhood-onset bipolar disorder.European child & adolescent psychiatry · 2022Article
- A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.Cell reports · 2022Article
- White matter correlates of cognitive flexibility in youth with bipolar disorder and typically developing children and adolescents.Psychiatry research. Neuroimaging · 2020Article
- A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.Molecular psychiatry · 2020Article
- Developmental evaluation of family functioning deficits in youths and young adults with childhood-onset bipolar disorder.Journal of affective disorders · 2018Article
- Vulnerabilities in sequencing and task switching in healthy youth offspring of parents with mood disorders.Journal of clinical and experimental neuropsychology · 2018Article
- Preliminary mapping of the structural effects of age in pediatric bipolar disorder with multimodal MR imaging.Psychiatry research. Neuroimaging · 2018Article
- Effects of adolescent exposure to methylmercury and d-amphetamine on reversal learning and an extradimensional shift in male mice.Experimental and clinical psychopharmacology · 2017Article
- Association of Lipid Peroxidation and Brain-Derived Neurotrophic Factor with Executive Function in Adolescent Bipolar Disorder.Psychopharmacology · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBipolar disorder (BD) is a severe mental illness that can have high costs for youths (<18 years old) and adults. Relative to healthy controls (HC), individuals with BD often show impaired attention, working memory, executive function, and cognitive flexibility (the ability to adapt to changing reward/punishment contingencies). In our study of youths and young adults with BD, we investigated 1) how cognitive flexibility varies developmentally in BD, and 2) whether it is independent of other executive function deficits associated with BD.
methodsWe measured errors on a reversal-learning task, as well as spatial working memory and other executive function, among participants with BD (N=75) and HC (N=130), 7-27 years old. Regression analyses focused on the effects of diagnosis on reversal-learning errors, controlling for age, gender, IQ, spatial span, and executive function. Similar analyses examined non-reversal errors to rule out general task impairment.
resultsParticipants with BD, regardless of age, gender, or cognitive ability, showed more errors than HC on the response reversal stages of the cognitive flexibility task. However, participants with BD did not show more errors on non-reversal stages, even when controlling for other variables. LIMITATIONS: Study limitations include the cross-sectional, rather than longitudinal, design; inability to measure non-linear age effects; and inclusion of medicated participants and those with psychiatric comorbidity.
conclusionsIndividuals with BD show a specific impairment in reversing a previously rewarded response, which persists across the transition from childhood to young adulthood. Tailored interventions targeting this deficit may be effective throughout this developmentally turbulent time.
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