ArticleNeuropsychology2016
Nonlinear associations between plasma cholesterol levels and neuropsychological function.
Article in Neuropsychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The influence of circulating cholesterol and its components in middle-aged adults on cognitive function at mid- and later-life; a systematic review.Frontiers in aging · 2025Pooled it
- Dyslipidemia and cerebral atrophy among health check-up individuals: A cross-sectional study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Sex-specific associations between serum lipid levels and cognitive performance in older adults: results from a cross-sectional real-world study.Aging clinical and experimental research · 2025Article
- Interactive Relations of Body Mass Index, Cardiorespiratory Fitness, and Sex to Cognitive Function in Older Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Change in cardiovascular health and rate of cognitive decline in older adults: a 15-year population-based study.BMC geriatrics · 2024Article
- Statin use is associated with higher white matter hyperintensity volumes and lower grey matter volumes.Brain communications · 2024Article
- The Effects of Statins on Cognitive Performance Are Mediated by Low-Density Lipoprotein, C-Reactive Protein, and Blood Glucose Concentrations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Article
- The Association between the Binding Processes of Working Memory and Vascular Risk Profile in Adults.Brain sciences · 2021Article
- Low Cholesterol Level Linked to Reduced Semantic Fluency Performance and Reduced Gray Matter Volume in the Medial Temporal Lobe.Frontiers in aging neuroscience · 2020Article
- Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study.Molecular neurodegeneration · 2019Article
- HDL Cholesterol Is Independently Associated with Cognitive Function in Males But Not in Females within a Cohort of Nonagenarians: The MUGELLO Study.The journal of nutrition, health & aging · 2019Article
- Serum Cholesterol and Incident Alzheimer's Disease: Findings from the Adult Changes in Thought Study.Journal of the American Geriatrics Society · 2018Article
- High Low-Density Lipoprotein Cholesterol Inversely Relates to Dementia in Community-Dwelling Older Adults: The Shanghai Aging Study.Frontiers in neurology · 2018Article
- Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals.Metabolic brain disease · 2017Article
- Plasma NfL and cognitive functioning in older adults: The moderating role of HDL cholesterol.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Internal Lipid Profile and Body Lipid Profile in Relation to Cognition: A Cross-Sectional Study in Southern China.American journal of Alzheimer's disease and other dementiasArticle
- Statins, cholesterol and cognition at the time of Alzheimer's disease diagnosis: A cross-sectional study from the Swedish registry for cognitive/dementia disorders.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveAlthough both high and low levels of total and low-density lipoprotein (LDL) cholesterol have been associated with poor neuropsychological function, little research has examined nonlinear effects. We examined quadratic relations of cholesterol to performance on a comprehensive neuropsychological battery.
methodParticipants were 190 older adults (53% men, ages 54-83) free of major medical, neurologic, and psychiatric disease. Measures of fasting plasma total and high-density lipoprotein (HDL) cholesterol were assayed, and LDL cholesterol was calculated. Participants completed neuropsychological measures of attention, executive function, memory, visuospatial judgment, and manual speed and dexterity. Multiple regression analyses examined cholesterol levels as quadratic predictors of each measure of cognitive performance, with age (dichotomized as <70 vs. 70+) as an effect modifier.
resultsA significant quadratic effect of Total Cholesterol² × Age was identified for Logical Memory II (
conclusionsResults indicate differential associations between cholesterol and neuropsychological function across different ages and domains of function. High and low total and LDL cholesterol may confer both risk and benefit for suboptimal cognitive function at different ages. (PsycINFO Database Record
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Registered trials
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