ArticlePloS one2016
Do Low Molecular Weight Agents Cause More Severe Asthma than High Molecular Weight Agents?
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Characteristics of Patients with Occupational Asthma in Türkiye, a Developing Country.Annals of global health · 2026Article
- Airway Epithelium: A Neglected but Crucial Cell Type in Asthma Pathobiology.Diagnostics (Basel, Switzerland) · 2023Review
- Effect of Different Molecular Weights of Polyacrylic Acid on Rat Lung Following Intratracheal Instillation.International journal of molecular sciences · 2022Article
- Occupational Asthma: The Knowledge Needs for a Better Management.Annals of work exposures and health · 2022Article
- Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death.American journal of industrial medicine · 2022Article
- The Impact of Ambient Environmental and Occupational Pollution on Respiratory Diseases.International journal of environmental research and public health · 2022Review
- A review on the effect of COVID-19 in type 2 asthma and its management.International immunopharmacology · 2021Review
- Skin Exposure Contributes to Chemical-Induced Asthma: What is the Evidence? A Systematic Review of Animal Models.Allergy, asthma & immunology research · 2020Review
- Causes and Phenotypes of Work-Related Asthma.International journal of environmental research and public health · 2020Review
- Progress in Occupational Asthma.International journal of environmental research and public health · 2020Review
- Bronchial Response to High and Low Molecular Weight Occupational Inhalant Allergens.Allergy, asthma & immunology research · 2020Article
- Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure?Chemical research in toxicology · 2019Article
- Occupational Respiratory Allergic Diseases in Healthcare Workers.Current allergy and asthma reports · 2016Review
- GEMA 5.3. Spanish Guideline on the Management of Asthma.Open respiratory archivesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to analyse whether patients with occupational asthma (OA) caused by low molecular weight (LMW) agents differed from patients with OA caused by high molecular weight (HMW) with regard to risk factors, asthma presentation and severity, and response to various diagnostic tests.
methodsSeventy-eight patients with OA diagnosed by positive specific inhalation challenge (SIC) were included. Anthropometric characteristics, atopic status, occupation, latency periods, asthma severity according to the Global Initiative for Asthma (GINA) control classification, lung function tests and SIC results were analysed.
resultsOA was induced by an HMW agent in 23 patients (29%) and by an LMW agent in 55 (71%). A logistic regression analysis confirmed that patients with OA caused by LMW agents had a significantly higher risk of severity according to the GINA classification after adjusting for potential confounders (OR = 3.579, 95% CI 1.136-11.280; p = 0.029). During the SIC, most patients with OA caused by HMW agents presented an early reaction (82%), while in patients with OA caused by LMW agents the response was mainly late (73%) (p = 0.0001). Similarly, patients with OA caused by LMW agents experienced a greater degree of bronchial hyperresponsiveness, measured as the difference in the methacholine dose-response ratio (DRR) before and after SIC (1.77, range 0-16), compared with patients with OA caused by HMW agents (0.87, range 0-72), (p = 0.024).
conclusionsOA caused by LMW agents may be more severe than that caused by HMW agents. The severity of the condition may be determined by the different mechanisms of action of these agents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.