Evidence map›Paper›PMID 27280452›Full record

ReviewSchizophrenia bulletin2016

Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations.

Ben Alderson-Day, Kelly Diederen, Charles Fernyhough, Judith M Ford, Guillermo Horga, Daniel S Margulies, Simon McCarthy-Jones, Georg Northoff, James M Shine, Jessica Turner and 4 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 6 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 6 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 8 countries.

Ben Alderson-DayPsychology Department, Durham University, Durham, UK; benjamin.alderson-day@durham.ac.uk.
Kelly DiederenDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK;
Charles FernyhoughPsychology Department, Durham University, Durham, UK;
Judith M FordDepartment of Psychiatry, School of Medicine, University of California, San Francisco, San Francisco, CA;
Guillermo HorgaNew York State Psychiatric Institute, Columbia University Medical Center, New York, NY;
Daniel S MarguliesMax Planck Research Group for Neuroanatomy & Connectivity, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany;
Simon McCarthy-JonesDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland;
Georg NorthoffMind, Brain Imaging and Neuroethics Research Unit, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada;
James M ShineDepartment of Psychology, Stanford University, Stanford, CA;
Jessica TurnerDepartment of Psychology, Neuroscience Institute, Georgia State University, Atlanta, GA;
Vincent van de VenFaculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands;
Remko van LutterveldCenter for Mindfulness, University of Massachusetts Medical School, Worcester, MA;
Flavie WatersNorth Metro Health Service Mental Health, Graylands Health Campus, School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia;
Renaud JardriUniv Lille, CNRS (UMR 9193), SCALab & CHU Lille, Psychiatry dept. (CURE), Lille, France.
Durham University · GBCentre Hospitalier Universitaire de Lille · FRColumbia University Irving Medical Center · USGeorgia State University · USMaastricht University · NLMax Planck Institute for Human Cognitive and Brain Sciences · DENorth Metropolitan Health Service · AUStanford University · USTrinity College Dublin · IEUniversity of California, San Francisco · USUniversity of Cambridge · GBUniversity of Massachusetts Chan Medical School · USWilfrid Laurier University · CA

Funding

Neural mechanisms of sensory predictions in schizophrenia with hallucinationsK23MH101637 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HORGA, GUILLERMO · 2014 to 2018
$862k
NIMH NIH HHS K23 MH101637Wellcome Trust WT098455Wellcome Trust WT103817
6 · The paper itself

Abstract

In recent years, there has been increasing interest in the potential for alterations to the brain's resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations.

Indexed as

BrainFunctional NeuroimagingHallucinationsHumansNerve NetSchizophreniadefault mode networkfMRIperceptionpsychosisschizophrenia

Identifiers

PMID27280452
PMCPMC4988751
OpenAlexW2412983219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.