Evidence map›Paper›PMID 27280412›Full record

SynthesisInternational journal of immunopathology and pharmacology2016

Hyaluronic acid: Perspectives in dentistry. A systematic review.

Manuele Casale, Antonio Moffa, Paola Vella, Lorenzo Sabatino, Francesco Capuano, Beatrice Salvinelli, Michele Antonio Lopez, Francesco Carinci, Fabrizio Salvinelli

3 registry-linked trialsOpen access · bronzeAbstract readEditorialSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of immunopathology and pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 95 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 6 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04675385 phase4completednot on this mapstarted 2019, after this paper: background citation

Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase

TypeinterventionalSponsorUniversity of Medicine and Pharmacy at Ho Chi Minh CityRan2019 to 2020Enrolled28ConditionsChronic Periodontitis, Hyaluronic AcidArms0.2% hyaluronic acid gel
NCT05768243 phase4completednot on this mapstarted 2021, after this paper: background citation

Efficiency of Hyaluronic Acid Versus Red Injectable Platelet-Rich Fibrin (i-PRF) in Treatment of Stage III Periodontitis (Randomized Controlled Clinical Trial)

TypeinterventionalSponsorBeirut Arab UniversityRan2021 to 2022Enrolled75ConditionsPeriodontitis Chronic Generalized SevereArmsHyaluronic acid, red injectable platelet rich fibrin (i-prf)
NCT07168811 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Comparative Clinical and Radiographic Evaluation of Hyaluronic Acid, TheraCal, and Mineral Trioxide Aggregate as Pulpotomy Agents in Primary Molars: A Randomized Clinical Trial

TypeinterventionalSponsorAl-Azhar UniversityRan2025 to 2026Enrolled66ConditionsPulpotomies Primary Teeth, Pulp Disease, DentalArmsHyaluronic Acid (HA), TheraCal, Mineral Trioxide Aggregate
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 6 syntheses or guidelines pooled it, 216 citations in OpenAlex.

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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Manuele CasaleUnit of Otolaryngology, University Campus Bio-Medico, Rome, Italy m.casale@unicampus.it.
Antonio MoffaUnit of Otolaryngology, University Campus Bio-Medico, Rome, Italy.
Paola VellaUnit of Otolaryngology, University Campus Bio-Medico, Rome, Italy.
Lorenzo SabatinoUnit of Otolaryngology, University Campus Bio-Medico, Rome, Italy.
Francesco CapuanoUnit of Otolaryngology, University Campus Bio-Medico, Rome, Italy.
Beatrice SalvinelliEuropean University of Madrid, Madrid, Spain.
Michele Antonio LopezUniversity of San Marino State, Italy.
Francesco CarinciDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Fabrizio SalvinelliUnit of Otolaryngology, University Campus Bio-Medico, Rome, Italy.
Università Campus Bio-Medico · ITUniversidad Europea de Madrid · ESUniversity of Ferrara · ITUniversity of the Republic of San Marino · SM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the soft periodontal tissue, gingiva, and periodontal ligament as well as to the hard tissue such as alveolar bone and cementum. Topical hyaluronic acid (HA) has recently been recognized as an adjuvant treatment for chronic inflammatory disease in addition to its use to improve healing after dental procedures. The aim of our work was to systematically review the published literature about potential effects of HA as an adjuvant treatment for chronic inflammatory disease, in addition to its use to improve healing after common dental procedures. Relevant published studies were found in PubMed, Google Scholar, and Ovid using a combined keyword search or medical subject headings. At the end of our study selection process, 25 relevant publications were included, three of them regarding gingivitis, 13 of them relating to chronic periodontitis, seven of them relating to dental surgery, including implant and sinus lift procedures, and the remaining three articles describing oral ulcers. Not only does topical administration of HA play a pivotal key role in the postoperative care of patients undergoing dental procedures, but positive results were also generally observed in all patients with chronic inflammatory gingival and periodontal disease and in patients with oral ulcers.

Indexed as

AnimalsChronic DiseaseDentistryGingivitisHumansHyaluronic AcidInflammationPeriodontitisHyaluronic Acidburning mouthgingivitishealinghyaluronanhyaluronic acidimplantmucositisoral mucous regenerationoral woundperiodontitissodium hyaluronatestomatitisteeth

Identifiers

PMID27280412
PMCPMC5806851
OpenAlexW2419628867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.