SynthesisPloS one2016
Diagnostic Performance of Indocyanine Green-Guided Sentinel Lymph Node Biopsy in Breast Cancer: A Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Meta-analysis Comparing Fluorescence Imaging with Radioisotope and Blue Dye-Guided Sentinel Node Identification for Breast Cancer Surgery.Annals of surgical oncology · 2021Pooled it
- Indocyanine Green Fluorescence Versus Blue Dye or Radioisotope Regarding Detection Rate of Sentinel Lymph Node Biopsy and Nodes Removed in Breast Cancer: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2020Pooled it
- Near-infrared fluorescence imaging for sentinel lymph node identification in colon cancer: a prospective single-center study and systematic review with meta-analysis.Techniques in coloproctology · 2019Pooled it
- Network meta-analysis of novel and conventional sentinel lymph node biopsy techniques in breast cancer.BJS open · 2019Pooled it
- Robotic-Assisted Sentinel Lymph Node Mapping With Indocyanine Green in Pelvic Malignancies: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2019Pooled it
- Sentinel lymph node biopsy using indocyanine green fluorescence in early-stage breast cancer: a meta-analysis.International journal of clinical oncology · 2017Pooled it
- Randomized comparison between indocyanine green fluorescence plusScientific reports · 2019Trial
- Sentinel Lymph Node Biopsy in Breast Cancer Patients by Means of Indocyanine Green Using the Karl Storz VITOM® Fluorescence Camera.BioMed research international · 2018Trial
- The Past, Present, and Future of Sentinel Lymph Node Biopsy in Breast Cancer.Annals of surgical oncology · 2026Review
- Comparison of Indocyanine Green Versus Isosulfan Blue in Melanoma Sentinel Node Biopsy.Annals of surgical oncology · 2026Article
- Article
- Comparison of Indocyanine Green Fluorescence and Technetium-99m for Sentinel Lymph Node Detection in Breast Cancer: A Retrospective Single-Center Study.Diagnostics (Basel, Switzerland) · 2026Article
- Indocyanine Green as a Single Tracer for Axillary Staging in Breast Cancer: A Retrospective Single-Centre Cohort Study.Cancers · 2026Article
- Article
- Cost-effectiveness analysis of different tracers (Patent Blue, Technetium-99 m, and Indocyanine Green) for Sentinel Lymph Node Biopsy procedure in breast cancer.Cost effectiveness and resource allocation : C/E · 2025Review
- Clinical Application of Multimodal Sentinel Lymph Node-Mapping Method for Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy: A Final Analysis.Annals of surgical oncology · 2025Article
- First study on the efficiency ofAnnals of nuclear medicine · 2025Article
- Radioactive nanosized colloids and indocyanine green identify the same sentinel lymph nodes in oral squamous cell carcinoma.Journal of cancer research and clinical oncology · 2023Article
- Evaluation of the efficacy of using indocyanine green associated with fluorescence in sentinel lymph node biopsy.PloS one · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnostic performance of indocyanine green (ICG) fluorescence-guided sentinel lymph node biopsy (SLNB) for the presence of metastases in breast cancer remains unclear.
objectiveWe performed a meta-analysis to investigate the diagnostic performance of ICG-guided SLNB.
methodsEligible studies were identified from searches of the databases PubMed and EMBASE up to September 2015. Studies that reported the detection rate of ICG fluorescence-guided SLNB with full axillary lymph node dissection and histological or immunohistochemical examinations were included. A meta-analysis was performed to generate pooled detection rate, sensitivity, specificity, false negative rate, diagnostic odds ratio (DOR) and a summary receiver operator characteristic curve (SROC).
resultsNineteen published studies were included to generate a pooled detection rate, comprising 2594 patients. The pooled detection rate was 0.98 (95% confidence interval [CI], 0.96-0.99). Six studies finally met the criteria for meta-analysis, which yielded a pooled sensitivity of 0.92 (95% CI, 0.85-0.96), specificity 1 (95% CI, 0.97-1), and DOR 311.47 (95% CI, 84.11-1153.39). The area under the SROC was 0.9758. No publication bias was found.
conclusionICG fluorescence-guided SLNB is viable for detection of lymph node metastases in breast cancer. Large-scale randomized multi-center trials are necessary to confirm our results.
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