ArticleJCI insight
Quantitative podocyte parameters predict human native kidney and allograft half-lives.
Article in JCI insight. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Mechanisms of Podocyte Injury in Kidney Allografts.Kidney360 · 2026Review
- Association of Podometric Parameters with the Oxford MEST-C Score and Pretreatment eGFR Slope in Patients with IgA Nephropathy.Kidney360 · 2026Article
- The growth hormone/IGF-1 axis is a risk factor for long-term kidney allograft failure.JCI insight · 2025Article
- Advancing the application of the analytical renal pathology system in allograft IgA nephropathy patients.Renal failure · 2024Article
- Recognition of intraglomerular histological features with deep learning in protocol transplant biopsies and their association with kidney function and prognosis.Clinical kidney journal · 2024Article
- Nephrons, podocytes and chronic kidney disease: Strategic antihypertensive therapy for renoprotection.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants.Kidney international · 2022Article
- Quantitative morphometrics reveals glomerular changes in patients with infrequent segmentally sclerosed glomeruli.Journal of clinical pathology · 2022Article
- Archetypal Analysis of Injury in Kidney Transplant Biopsies Identifies Two Classes of Early AKI.Frontiers in medicine · 2022Article
- Urine marker analysis identifies evidence for persistent glomerular podocyte injury across allograft lifespan.Clinical transplantation · 2021Article
- Critical timing of ACEi initiation prevents compensatory glomerular hypertrophy in the remaining single kidney.Scientific reports · 2021Article
- Podocyte density is reduced in kidney allografts with high-risk APOL1 genotypes at transplantation.Clinical transplantation · 2021Article
- Podocyte stress and detachment measured in urine are related to mean arterial pressure in healthy humans.Kidney international · 2020Observational
- Mechanisms of Metabolic Acidosis-Induced Kidney Injury in Chronic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2020Article
- Podocyte hypertrophic stress and detachment precedes hyperglycemia or albuminuria in a rat model of obesity and type2 diabetes-associated nephropathy.Scientific reports · 2019Article
- Accelerated podocyte detachment early after kidney transplantation is related to long-term allograft loss of function.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Observational
- BDNF: mRNA expression in urine cells of patients with chronic kidney disease and its role in kidney function.Journal of cellular and molecular medicine · 2018Article
- Accelerated podocyte detachment and progressive podocyte loss from glomeruli with age in Alport Syndrome.Kidney international · 2017Article
- Podocyte number and density changes during early human life.Pediatric nephrology (Berlin, Germany) · 2017Article
- Molecular assessment of disease states in kidney transplant biopsy samples.Nature reviews. Nephrology · 2016Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundKidney function decreases with age. A potential mechanistic explanation for kidney and allograft half-life has evolved through the realization that linear reduction in glomerular podocyte density could drive progressive glomerulosclerosis to impact both native kidney and allograft half-lives.
methodsPredictions from podometrics (quantitation of podocyte parameters) were tested using independent pathologic, functional, and outcome data for native kidneys and allografts derived from published reports and large registries.
resultsWith age, native kidneys exponentially develop glomerulosclerosis, reduced renal function, and end-stage kidney disease, projecting a finite average kidney life span. The slope of allograft failure rate versus age parallels that of reduction in podocyte density versus age. Quantitative modeling projects allograft half-life at any donor age, and rate of podocyte detachment parallels the observed allograft loss rate.
conclusionNative kidneys are designed to have a limited average life span of about 100-140 years. Allografts undergo an accelerated aging-like process that accounts for their unexpectedly short half-life (about 15 years), the observation that older donor age is associated with shorter allograft half-life, and the fact that long-term allograft survival has not substantially improved. Podometrics provides potential readouts for these processes, thereby offering new approaches for monitoring and intervention.
fundingNational Institutes of Health.
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Registered trials
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