ReviewCardiovascular diagnosis and therapy2016
Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?
Review in Cardiovascular diagnosis and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021Pooled it
- Value of Progression of Coronary Artery Calcification for Risk Prediction of Coronary and Cardiovascular Events: Result of the HNR Study (Heinz Nixdorf Recall).Circulation · 2018Trial
- Early detection of cardiovascular disease in chest population screening: challenges for a rapidly emerging cardiac CT application.The British journal of radiology · 2025Review
- Progression of arterial calcifications: what, where, and in whom?European radiology · 2024Article
- Progression of Coronary Artery Calcification According to Changes in Risk Factors in Asymptomatic Individuals.Journal of personalized medicine · 2024Article
- Association of cardiovascular health with subclinical coronary atherosclerosis progression among five racial and ethnic groups: The MASALA and MESA studies.Atherosclerosis · 2024Article
- Risk Factor Interactions, Non-High-Density Lipoprotein Cholesterol to Apolipoprotein B Ratio, and Severity of Coronary Arteriosclerosis in South Asian Individuals: An Observational Cohort Study.Journal of the American Heart Association · 2023Observational
- Neuromedin B modulates phosphate-induced vascular calcification.BMB reports · 2021Article
- Article
- Investigation of Specific Proteins Related to Different Types of Coronary Atherosclerosis.Frontiers in cardiovascular medicine · 2021Article
- Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease.Coronary artery disease · 2020Article
- Traffic-Related Air Pollution and Carotid Plaque Burden in a Canadian City With Low-Level Ambient Pollution.Journal of the American Heart Association · 2020Article
- Atherosclerotic plaque burden evaluated from neck to groin: effect of gender and cardiovascular risk factors.The international journal of cardiovascular imaging · 2019Observational
- Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases.PloS one · 2019Article
- Dynamic of changes in coronary artery calcification in early rheumatoid arthritis patients over 18 months.Rheumatology international · 2018Article
- The annual rate of coronary artery calcification with combination therapy with a PCSK9 inhibitor and a statin is lower than that with statin monotherapy.NPJ aging and mechanisms of disease · 2018Article
- Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia.Atherosclerosis · 2017Article
- Intervention Effects of Atorvastatin Combined withPharmacognosy magazineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery calcification (CAC) has been strongly established as an independent predictor of adverse events, with a significant incremental prognostic value over traditional risk stratification algorithms. CAC progression has been associated with a higher rate of events. In parallel, several randomized studies and meta-analysis have shown the effectiveness of statins to slow progression and even promote plaque regression. However, evidence regarding the effect of routine medical therapy on CAC has yielded conflicting results, with initial studies showing significant CAC regression, and contemporaneous data showing rather the opposite. Accordingly, there is currently a great controversy on whether progression of CAC is a sign of progression or stabilization of coronary artery disease (CAD). The finding of inexorable CAC progression despite the implementation of intensive contemporaneous medical therapy suggests that further understanding of this phenomenon should be undertaken before the implementation of CAC as a surrogate endpoint for longitudinal studies, or for prospective follow-up of patients under routine medical treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.