Evidence map›Paper›PMID 27280086›Full record

ArticleCardiovascular diagnosis and therapy2016

Utility of brain natriuretic peptide assay as a predictor of short term outcomes in patients presenting with syncope to the emergency department.

Ahmad Isbitan, Amer Hawatmeh, Yaser Elnahar, Kunal Patel, Zaid Altheeb, Vincent Debari, Ayman Hamdan, Fayez Shamoon

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Article in Cardiovascular diagnosis and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmad Isbitan1 Department of Cardiology, Saint Michael's Medical Center, New York Medical College, New Jersey, USA ; 2 Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA ; 3 Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Amer Hawatmeh1 Department of Cardiology, Saint Michael's Medical Center, New York Medical College, New Jersey, USA ; 2 Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA ; 3 Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Yaser Elnahar1 Department of Cardiology, Saint Michael's Medical Center, New York Medical College, New Jersey, USA ; 2 Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA ; 3 Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Kunal Patel1 Department of Cardiology, Saint Michael's Medical Center, New York Medical College, New Jersey, USA ; 2 Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA ; 3 Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Zaid Altheeb1 Department of Cardiology, Saint Michael's Medical Center, New York Medical College, New Jersey, USA ; 2 Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA ; 3 Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Vincent Debari1 Department of Cardiology, Saint Michael's Medical Center, New York Medical College, New Jersey, USA ; 2 Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA ; 3 Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Ayman Hamdan1 Department of Cardiology, Saint Michael's Medical Center, New York Medical College, New Jersey, USA ; 2 Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA ; 3 Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Fayez Shamoon1 Department of Cardiology, Saint Michael's Medical Center, New York Medical College, New Jersey, USA ; 2 Department of Cardiology, Saint Joseph Regional Medical Center, New York Medical College, New Jersey, USA ; 3 Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSyncope is a common condition that accounts for 3% of emergency department (ED) visits and 1-6% of hospital admissions. Current admissions practices result in marginal diagnostic and therapeutic benefit and consume healthcare resources.

methodsThis prospective cohort study examined the use of brain natriuretic peptide (BNP) test as a predictor of short term serious outcome in 159 patients who presented to ED with syncope between August 2012 and August 2013 in two tertiary teaching medical centers.

resultsA total of 41 patients (36%) had serious outcomes within 1 month, 21 of them were in the low BNP group and 20 were in the high BNP group. There was a significantly higher incidence of serious outcomes, myocardial infarction (MI), and life-threatening arrhythmias in the high BNP group. Patients with BNP >250 has an 8.844 fold increase risk of serious outcomes [odds ratio (OR) 8.844, 95% CI: (3.281 to 23.8), P<0.001], a 14.8-fold increase risk of MI [OR =14.8, 95% CI: (1.57 to 139), P=0.011], and a 4.46-fold increase risk life threatening arrhythmia [OR =4.46, 95% CI: (1.15-18.8), P=0.034]. However, there was no statistically significant difference between the two groups in one month mortality, major bleeding, major cardiac procedures or stroke.

conclusionsOur study results further validates the ROSE rule and the utility of BNP in risk stratification of syncope patients. This study showed that measuring BNP and adding ROSE rule to the standard evaluation of syncope can sufficiently predict short-term serious outcomes for patients presenting to ED with syncope.

Indexed as

brain natriuretic peptide (BNP)emergency medicineROSE ruleSyncope

Identifiers

PMID27280086
PMCPMC4880755

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.