Evidence map›Paper›PMID 27280016›Full record

ArticleChiropractic & manual therapies2016

Dose-response of spinal manipulation for cervicogenic headache: study protocol for a randomized controlled trial.

Linda Hanson, Mitchell Haas, Gert Bronfort, Darcy Vavrek, Craig Schulz, Brent Leininger, Roni Evans, Leslie Takaki, Moni Neradilek

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chiropractic & manual therapies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01530321 (Dose-Response of Manipulation for Cervicogenic Headache), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01530321 phase1 / phase2completednot on this map

Dose-Response of Manipulation for Cervicogenic Headache

TypeinterventionalSponsorUniversity of Western StatesRan2012 to 2016Enrolled256ConditionsCervicogenic HeadacheArmsSpinal Manipulation, Light Massage
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Linda HansonCenter for Spirituality and Healing, The University of Minnesota, 420 Delaware St SE C592, Minneapolis, MN 55455 USA.
Mitchell HaasCenter for Outcome Studies, The University of Western States, 2900 NE 132nd Ave, Portland, OR 97230 USA.
Gert BronfortCenter for Spirituality and Healing, The University of Minnesota, 420 Delaware St SE C592, Minneapolis, MN 55455 USA.
Darcy VavrekBiostatistics, Clinical and Regulatory Affairs, Illumina, 5200 Illumina Way, San Diego, CA 92122 USA.
Craig SchulzCenter for Spirituality and Healing, The University of Minnesota, 420 Delaware St SE C592, Minneapolis, MN 55455 USA ; Children's Hospitals and Clinics of Minnesota, Pain, Palliative Care, and Integrative Medicine, 2525 Chicago Ave, Minneapolis, MN 55404 USA.
Brent LeiningerCenter for Spirituality and Healing, The University of Minnesota, 420 Delaware St SE C592, Minneapolis, MN 55455 USA.
Roni EvansCenter for Spirituality and Healing, The University of Minnesota, 420 Delaware St SE C592, Minneapolis, MN 55455 USA.
Leslie TakakiCenter for Outcome Studies, The University of Western States, 2900 NE 132nd Ave, Portland, OR 97230 USA.
Moni NeradilekThe Mountain-Whisper-Light Statistics, 1827 23rd Ave East, Seattle, WA 98112 USA.
University of Minnesota · USUniversity of Western States · USIllumina (United States) · US

Funding

Dose-Response of Manipulation for Cervicogenic HeadacheR01AT006330 · NCCIH · UNIVERSITY OF WESTERN STATES · PI BRONFORT, GERT, HAAS, MITCHELL · 2011 to 2015
$3.3M
Cost effectiveness of manipulation for spine pain using individual patient dataK01AT008965 · NCCIH · UNIVERSITY OF MINNESOTA · PI LEININGER, BRENT · 2016 to 2020
$559k
NCCIH NIH HHS K01 AT008965NCCIH NIH HHS R01 AT006330
6 · The paper itself

Abstract

backgroundCervicogenic headache is a prevalent and costly pain condition commonly treated by chiropractors. There is evidence to support the effectiveness for spinal manipulation, but the dose of treatment required to achieve maximal relief remains unknown. The purpose of this paper is to describe the methodology for a randomized controlled trial evaluating the dose-response of spinal manipulation for chronic cervicogenic headache in an adult population. METHODS/

designThis is a mixed-methods, two-site, prospective, parallel groups, observer-blind, randomized controlled trial conducted at university-affiliated research clinics in the Portland, OR and Minneapolis, MN areas. The primary outcome is patient reported headache frequency. Other outcomes include self-reported headache intensity, disability, quality of life, improvement, neck pain intensity and frequency, satisfaction, medication use, outside care, cervical motion, pain pressure thresholds, health care utilization, health care costs, and lost productivity. Qualitative interviews are also conducted to evaluate patients' expectations of treatment. DISCUSSION: With growing concerns regarding the costs and side effects of commonly used conventional treatments, greater numbers of headache sufferers are seeking other approaches to care. This is the first full-scale randomized controlled trial assessing the dose-response of spinal manipulation therapy on outcomes for cervicogenic headache. The results of this study will provide important evidence for the management of cervicogenic headache in adults.

trial registrationClinicalTrials.gov (Identifier: NCT01530321).

Indexed as

Cervicogenic headacheChiropracticMixed methodsRandomized controlled trialSpinal manipulation

Identifiers

PMID27280016
PMCPMC4898300
OpenAlexW2413296511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.