ArticleArchives of medical science : AMS2016
Empirical use of antibiotic therapy in the prevention of early onset sepsis in neonates: a pilot study.
Article in Archives of medical science : AMS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 335 citations in OpenAlex.
- Shorter versus longer duration antibiotic regimens for treatment of suspected neonatal sepsis.The Cochrane database of systematic reviews · 2024Pooled it
- Antibiotic regimens for early-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Antibiotic regimens for late-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Neonatal sepsis and its associated factors among asphyxiated newborns admitted in West Oromia Tertiary Hospitals, Ethiopia.Scientific reports · 2026Article
- Machine learning for prediction of in-ICU mortality in sepsis: an observational study using the MIMIC IV database.Archives of medical science : AMS · 2026Article
- Article
- Neonatology: First Exposure to Antibiotics from the Ethical Perspective of Parents, Physicians, and Regulators.Antibiotics (Basel, Switzerland) · 2025Article
- Evaluation of criterion-based audit in improving quality of neonatal birth asphyxia care at Balaka district hospital in Malawi.Maternal health, neonatology and perinatology · 2024Article
- Shorter versus longer duration antibiotic regimens for treatment of culture-positive neonatal sepsis.The Cochrane database of systematic reviews · 2024Article
- Prevalence and antibiotic resistance pattern of bacteria from sepsis suspected neonates at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.BMC pediatrics · 2023Article
- Antibiotic safety among neonates and paediatrics in a public hospital: KwaZulu-Natal.Health SA = SA Gesondheid · 2023Article
- Evaluation of Adverse Drug Reactions in Paediatric Patients: A Retrospective Study in Turkish Hospital.Frontiers in pharmacology · 2021Article
- Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis.Systematic reviews · 2019Article
- Duration of empirical therapy in neonatal bacterial meningitis with third generation cephalosporin: a multicenter retrospective study.Archives of medical science : AMS · 2019Article
- Impact of antenatal oxytocin infusion on neonatal respiratory morbidity associated with elective cesarean section.Archives of medical science : AMS · 2017Article
- Reported Adverse Drug Reactions in Infants: A Nationwide Analysis in Malaysia.Frontiers in pharmacology · 2017Article
- Group B Streptococcus Colonization among Saudi Women During Labor.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo identify and assess the characteristics, risk and outcome of neonates treated with empiric antibiotics for suspected early onset sepsis (EOS). MATERIAL AND
methodsThis is a retrospective study conducted at a Malaysian government hospital. Records of neonatal patients admitted within 72 h of life and prescribed with empirical antibiotic therapy for suspected EOS were reviewed.
resultsThree hundred and twenty-three cases met the inclusion criteria and were divided into gestational age (premature < 36 weeks; term ≥ 37 weeks) and birth weight (low birth weight (LBW) < 2.5 kg; normal body weight (NBW) ≥ 2.5 kg) groups. Premature (n = 197) and LBW (n = 194) neonates required significantly longer hospital stay, a higher degree of ventilator support and more surfactant (p = 0.001). More than 90.0% of premature and LBW neonates were diagnosed with respiratory distress syndrome, congenital pneumonia and presumed sepsis. Term (n = 123) and NBW (n = 129) neonates had greater maternal risk factors, especially meconium-stained amniotic fluid (MSAF) and perinatal asphyxia. The incidence of demonstrated EOS was 3.1%. Crystalline penicillin plus gentamicin was the standard therapy for all groups and was started within 24 h of life, with a mean treatment duration of ∼4 days. The treatment success rate was 89.0%, and only LBW neonates showed a higher risk of overall treatment failure (OR = 3.75; 95% CI: 1.22-11.53). Seventy-four percent of term and NBW neonates discharged well, while 42.0% of premature and LBW neonates required referral.
conclusionsCrystalline penicillin plus gentamicin prescribed within 24 h of life is effective in the prevention of EOS. However, low birth weight neonates have a higher risk of treatment failure.
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