Evidence map›Paper›PMID 27279750›Full record

ArticleGenetics & epigenetics2016

A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children.

Daniel Amoako-Sakyi, Selorme Adukpo, Kwadwo A Kusi, Daniel Dodoo, Michael F Ofori, George O Adjei, Dominic E Edoh, Richard H Asmah, Charles Brown, Bright Adu and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics & epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Microorganisms · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Daniel Amoako-SakyiDepartment of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.; Immunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Selorme AdukpoImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.; Institute of Tropical Medicine, Eberhard Karls University, Tübingen, Germany.
Kwadwo A KusiImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Daniel DodooImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Michael F OforiImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
George O AdjeiDepartment of Child Health, School of Medicine and Dentistry, College of Health Science, University of Ghana, Legon, Accra, Ghana.; Centre for Tropical Clinical Pharmacology and Therapeutics, School of Medicine and Dentistry, Centre for Tropical Clinical Pharmacology and Therapeutics, Legon, Accra, Ghana.
Dominic E EdohDepartment of Animal Biology and Conservation Science, University of Ghana, Legon, Accra, Ghana.
Richard H AsmahDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.
Charles BrownDepartment of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.
Bright AduImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
Dorcas Obiri-YeboahDepartment of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Godfred FutagbiDepartment of Animal Biology and Conservation Science, University of Ghana, Legon, Accra, Ghana.
Sharif Buari AbubakariDepartment of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.
Marita Troye-BlombergDepartment of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Bartholomew D AkanmoriImmunization and Vaccines Development Programme, Family & Reproductive Health Cluster, WHO Regional Office for Africa, Brazzaville, Congo.
Bamenla Q GokaDepartment of Child Health, School of Medicine and Dentistry, College of Health Science, University of Ghana, Legon, Accra, Ghana.
John Arko-MensahDepartment of Biological, Environmental and Occupational Health, School of Public Health, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.
Ben A GyanImmunology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
University of Ghana · GHNoguchi Memorial Institute for Medical Research · GHUniversity of Cape Coast · GHStockholm University · SE

Funding

World Health Organization 001
6 · The paper itself

Abstract

Malaria pathogenesis may be influenced by IgE responses and cytokine cross-regulation. Several mutations in the IL-4/STAT6 signaling pathway can alter cytokine cross-regulation and IgE responses during a Plasmodium falciparum malarial infection. This study investigated the relationship between a STAT6 intronic single-nucleotide polymorphism (rs3024974), total IgE, cytokines, and malaria severity in 238 Ghanaian children aged between 0.5 and 13 years. Total IgE and cytokine levels were measured by ELISA, while genotyping was done by polymerase chain reaction-restriction fragment length polymorphism (RFLP). Compared with healthy controls, heterozygosity protected against clinical malaria: uncomplicated malaria (odds ratios [OR] = 0.13, P < 0.001), severe malarial anemia (OR = 0.18, P < 0.001), and cerebral malaria (OR = 0.39, P = 0.022). Levels of total IgE significantly differed among malaria phenotypes (P = 0.044) and rs3024974 genotypes (P = 0.037). Neither cytokine levels nor IL-6/IL-10 ratios were associated with malaria phenotypes or rs3024974 genotypes. This study suggests a role for rs3024974 in malaria pathogenesis and offers further insights into an IL-4/STAT6 pathway mutation in malaria pathogenesis.

Indexed as

GhanaIgEintronmalariars3024974SNPSTAT6

Identifiers

PMID27279750
PMCPMC4887113
OpenAlexW2405070100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.