Evidence map›Paper›PMID 27279711›Full record

ArticlePharmacognosy magazine2016

Phytochemicals from Tradescantia albiflora Kunth Extracts Reduce Serum Uric Acid Levels in Oxonate-induced Rats.

Wen-Ling Wang, Shi-Yuan Sheu, Wen-Dar Huang, Ya-Ling Chuang, Han-Chun Tseng, Tzann-Shun Hwang, Yuan-Tsung Fu, Yueh-Hsiung Kuo, Chun-Hsu Yao, Tzong-Fu Kuo

Abstract read
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In one paragraph

Article in Pharmacognosy magazine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Evaluation of the anti-gout effect ofMedicine and pharmacy reports · 2021
    Article
  3. Article
  4. Phytochemical Investigation ofMolecules (Basel, Switzerland) · 2019
    Article
  5. Hypouricemic Effect of Ethanol Extract ofClinical nutrition research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wen-Ling WangSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Chinese Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Shi-Yuan SheuSchool of Medicine, Chung Shan Medical University, Taipei, Taiwan; Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taipei, Taiwan; Department of Occupational Therapy, Asia University, Taipei, Taiwan.
Wen-Dar HuangDepartment of Agronomy, National Taiwan University, Taipei, Taiwan.
Ya-Ling ChuangDepartment of School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
Han-Chun TsengDepartment of Chemistry, National Taiwan University, Taipei, Taiwan.
Tzann-Shun HwangGraduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan.
Yuan-Tsung FuDepartment of Chinese Medicine, Buddhist Tzu Chi General Hospital, Taichung Branch, Taiwan; Department of School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.
Yueh-Hsiung KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan; Department of Biotechnology, Asia University, Taipei, Taiwan.
Chun-Hsu YaoSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan; Department of Biomedical Informatics, Asia University, Taipei, Taiwan.
Tzong-Fu KuoDepartment of School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; Department of Post-Baccalaureate Veterinary Medicine, Asia University, Taipei, Taiwan.
National Taiwan University · TWChina Medical University · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTradescantia albiflora (TA) Kunth (Commelinaceae) has been used for treating gout and hyperuricemia as folklore remedies in Taiwan. Therefore, it is worthwhile to study the effect of TA extracts on lowering uric acid activity. The hypouricemic effects of TA extracts on potassium oxonate (PO)-induced acute hyperuricemia were investigated for the first time. MATERIALS AND

methodsAll treatments at the same volume (1 ml) were orally administered to the abdominal cavity of PO-induced hyperuricemic rats. One milliliter of TA extract in n-hexane (HE), ethyl acetate (EA), n-butanol (BuOH), and water fractions has 0.28, 0.21, 0.28, and 1.03 mg TA, respectively; and the plasma uric acid (PUA) level was measured for a consecutive 4 h after administration.

resultsAll four fractions' extracts derived from TA were observed to significantly reduce PUA compared with the PO group. The EA-soluble fraction (TA-EA) exhibited the best xanthine oxidase (XO) inhibitory activity. Following column chromatography, 12 phytochemicals were isolated and identified from the EA fraction. The IC50 values of isolated phytochemicals indicated that bracteanolide A (AR11) showed the remarkable XO inhibitory effect (IC50 value of 76.4 μg/ml). These findings showed that the in vivo hypouricemic effect in hyperuricemic rats was consistent with in vitro XO inhibitory activity, indicating that TA extracts and derived phytochemicals could be potential candidates as hypouricemic agents. SUMMARY: Tradescantia albiflora extracts possess in vivo hypouricemic action in hyperuricemic ratsT. albiflora extracts exhibited strong inhibitory activity against xanthine oxidase (XO)Butenolide may play an important role in XO inhibitionThe extract bracteanolide A was demonstrated potent XO inhibitory activity in vitro. Abbreviations used: TA: Tradescantia albiflora, PO: potassium oxonate, HE: n-hexane, EA: ethyl acetate, BuOH: n-butanol, PUA: plasma uric acid, XO: xanthine oxidase, MeOH: methanol, IP: intraperitoneal.

Indexed as

HyperuricemiaTradescantia albiflora Kunthuric acidxanthine oxidase

Identifiers

PMID27279711
PMCPMC4883083
OpenAlexW2328041814

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.