ArticleBritish journal of clinical pharmacology2016
Performance of trigger tools in identifying adverse drug events in emergency department patients: a validation study.
Article in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of adverse drug reactions in the primary care setting: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Implementing a clinical pharmacy intervention for older adult inpatients with chronic non-cancer pain: a feasibility study.International journal of clinical pharmacy · 2026Article
- Performance of Trigger Tools in Identifying Adverse Drug Events in Emergency Intensive Care Unit: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Drug-Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources.Clinical pharmacology and therapeutics · 2025Article
- The doMESTIC RISK Tool: Prioritising Home-Care Patients for Clinical Pharmacy Services with the Help of a Delphi Study.Nursing reports (Pavia, Italy) · 2025Article
- Article
- Establishing a trigger tool based on global trigger tools to identify adverse drug events in obstetric inpatients in China.BMC health services research · 2024Review
- Active monitoring of antifungal adverse events in hospitalized patients based on Global Trigger Tool method.Frontiers in pharmacology · 2024Article
- Sharing Adverse Drug Event Reports Between Hospitals and Community Pharmacists to Inform Re-dispensing: An Analysis of Reports and Process Outcomes.Drug safety · 2023Observational
- Frequency, Characteristics, and Predictive Factors of Adverse Drug Events in an Adult Emergency Department according to Age: A Cross-Sectional Study.Journal of clinical medicine · 2022Article
- Translation and Validation of the Indonesian Version of the Adverse Drug Reaction Severity Level Instruments in Colorectal Cancer Patients.Journal of multidisciplinary healthcare · 2022Article
- Development and Validation of a Trigger Tool for Identifying Drug-Related Emergency Department Visits.International journal of environmental research and public health · 2021Article
- Development and Implementation of an e-Trigger Tool for Adverse Drug Events in a Swiss University Hospital.Drug, healthcare and patient safety · 2021Article
- Alert Override Patterns With a Medication Clinical Decision Support System in an Academic Emergency Department: Retrospective Descriptive Study.JMIR medical informatics · 2020Article
- Translation, Cross-Cultural Adaptation, and Measurement Properties of the Portuguese Version of the Global Trigger Tool for Adverse Events.Therapeutics and clinical risk management · 2020Article
- Identifying medication harm in hospitalised patients: a bimodal, targeted approach.Therapeutic advances in drug safety · 2020Article
- Understanding adverse drug-related emergency department visits: development of a conceptual model through a systematic review.Therapeutic advances in drug safety · 2019Review
- Evaluation of accuracy of IHI Trigger Tool in identifying adverse drug events: a prospective observational study.British journal of clinical pharmacology · 2018Observational
- Antihypertensive-related adverse drug reactions among older hospitalized adults.International journal of clinical pharmacy · 2018Article
- Why Clinicians Don't Report Adverse Drug Events: Qualitative Study.JMIR public health and surveillance · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTrigger tools are retrospective surveillance methods that can be used to identify adverse drug events (ADEs), unintended and harmful effects of medications, in medical records. Trigger tools are used in quality improvement, public health surveillance and research activities. The objective of the study was to evaluate the performance of trigger tools in identifying ADEs.
methodsThis study was a sub-study of a prospective cohort study which enrolled adults presenting to one tertiary care emergency department. Clinical pharmacists evaluated patients for ADEs at the point-of-care. Twelve months after the prospective study's completion, the patients' medical records were reviewed using eight different trigger tools. ADEs identified using each trigger tool were compared with events identified at the point-of-care. The primary outcome was the sensitivity of each trigger tool for ADEs.
resultsAmong 1151 patients, 152 (13.2%, 95% confidence intervals (CI) 11.4, 15.3%) were diagnosed with one or more ADEs at the point-of-care. The sensitivity of the trigger tools for detecting ADEs ranged from 2.6% (95% CI 0.7, 6.6%) to 15.8% (95% CI 10.6, 22.8%). Their specificity varied from 99.3% (95% CI 98.6, 99.7) to 100% (95% CI 99.6, 100%).
conclusionThe trigger tools examined had poor sensitivity for identifying ADEs in emergency department patients, when applied manually and in retrospect. Reliance on these methods to detect ADEs for quality improvement, surveillance, and research activities is likely to underestimate their occurrence, and may lead to biased estimates.
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