ArticleScientific reports2016
Cytochrome bd Displays Significant Quinol Peroxidase Activity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 81 citations in OpenAlex.
- Aerotolerant capacity of the lung symbiontJournal of bacteriology · 2026Article
- The role of cytochrome oxidases in bacterial virulence.Infection and immunity · 2026Review
- The Crucial Role of LTTR_0390 inJournal of agricultural and food chemistry · 2026Article
- A cytochromeApplied and environmental microbiology · 2025Article
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- Cyanide Insensitive Oxidase Confers Hydrogen Sulfide and Nitric Oxide Tolerance toAntioxidants (Basel, Switzerland) · 2024Article
- Membrane-Bound Redox Enzyme CytochromeInternational journal of molecular sciences · 2024Article
- The respiratory chain ofFrontiers in microbiology · 2024Article
- Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases.Scientific reports · 2023Article
- Genome-centered metagenomics illuminates adaptations of core members to a partial Nitritation-Anammox bioreactor under periodic microaeration.Frontiers in microbiology · 2023Article
- Genome-centric insight into metabolically active microbial population in shallow-sea hydrothermal vents.Microbiome · 2022Article
- Bioenergetics and Reactive Nitrogen Species in Bacteria.International journal of molecular sciences · 2022Review
- Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria.Microorganisms · 2022Review
- Recent Advances in Structural Studies of CytochromeInternational journal of molecular sciences · 2022Review
- Evolution of the cytochrome bd oxygen reductase superfamily and the function of CydAA' in Archaea.The ISME journal · 2021Article
- Impact of Hydrogen Sulfide on Mitochondrial and Bacterial Bioenergetics.International journal of molecular sciences · 2021Review
- Central Carbon Metabolism, Sodium-Motive Electron Transfer, and Ammonium Formation by the Vaginal PathogenInternational journal of molecular sciences · 2021Article
- Proton Pumping and Non-Pumping Terminal Respiratory Oxidases: Active Sites Intermediates of These Molecular Machines and Their Derivatives.International journal of molecular sciences · 2021Review
- Revisiting long-chain fatty acid metabolism in Escherichia coli: integration with stress responses.Current genetics · 2021Review
- Bacterial Oxidases of the CytochromeAntioxidants & redox signaling · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome bd is a prokaryotic terminal oxidase that catalyses the electrogenic reduction of oxygen to water using ubiquinol as electron donor. Cytochrome bd is a tri-haem integral membrane enzyme carrying a low-spin haem b558, and two high-spin haems: b595 and d. Here we show that besides its oxidase activity, cytochrome bd from Escherichia coli is a genuine quinol peroxidase (QPO) that reduces hydrogen peroxide to water. The highly active and pure enzyme preparation used in this study did not display the catalase activity recently reported for E. coli cytochrome bd. To our knowledge, cytochrome bd is the first membrane-bound quinol peroxidase detected in E. coli. The observation that cytochrome bd is a quinol peroxidase, can provide a biochemical basis for its role in detoxification of hydrogen peroxide and may explain the frequent findings reported in the literature that indicate increased sensitivity to hydrogen peroxide and decreased virulence in mutants that lack the enzyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.