Evidence map›Paper›PMID 27279240›Full record

ReviewCritical reviews in oncogenesis2015

Review of the GAS3 Family of Proteins and their Relevance to Cancer.

Negin Ashki, Lynn Gordon, Madhuri Wadehra

Open access · greenAbstract readReview
In one paragraph

Review in Critical reviews in oncogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. EMP3: A promising biomarker for tumor prognosis and targeted cancer therapy.Cancer biomarkers : section A of Disease markers · 2024
    Review
  3. Review
  4. Review
  5. Article
  6. Genetic Deletion ofFrontiers in medicine · 2019
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Negin AshkiDepartment of Ophthalmology, Jules Stein Eye Institute, Los Angeles, CA.
Lynn GordonDepartment of Ophthalmology, Jules Stein Eye Institute, Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Madhuri WadehraPathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA; Center to Eliminate Cancer Health Disparities, Charles Drew University, Los Angeles, CA.
Charles R. Drew University of Medicine and Science · USDoheny Eye Institute · US

Funding

Using EMP2 for Image Guided Drug Delivery for Breast CancerR01CA163971 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLAFSEN, TOVE, WADEHRA, MADHURI · 2012 to 2016
$1.6M
NCI NIH HHS R01 CA163971
6 · The paper itself

Abstract

The GAS3 family of tetraspan proteins has recently been implicated in the progression of cancer. Currently, six members of the GAS3 family have been identified in humans and mice, and while their expressions in disease vary, data suggest that they play a role in epithelial cell structure and function. In this review, we highlight the studies implicating four of the members in disease pathogenesis as well as probe the structural similarities between the family members. Finally, the impact of targeting select members of the family such as PMP22 and EMP2 is discussed.

Indexed as

AnimalsEpithelial CellsHumansMembrane GlycoproteinsMiceMyelin ProteinsNeoplasm ProteinsNeoplasmsReceptors, Cell SurfaceEMP2 protein, humanEMP3 protein, humanepithelial membrane protein-1Membrane GlycoproteinsMyelin ProteinsNeoplasm ProteinsPMP22 protein, humanPmp22 protein, mouseReceptors, Cell Surface

Identifiers

PMID27279240
PMCPMC5362274
OpenAlexW2403541837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.