ReviewInvertebrate neuroscience : IN2016
How do the macrocyclic lactones kill filarial nematode larvae?
Review in Invertebrate neuroscience : IN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- Lack of detectable short-term effects of a single dose of ivermectin on the human immune system.Parasites & vectors · 2021Trial
- Evaluation of the Cardiac Safety of Long-Acting Endectocide Moxidectin in a Randomized Concentration-QT Study.Clinical and translational science · 2018Trial
- Canine Ticks, Tick-Borne Pathogens and Associated Risk Factors in Nigeria.Pathogens (Basel, Switzerland) · 2025Article
- Efficacy of moxidectin, using various dose regimens, against JYD-34, a macrocyclic lactone resistant isolate of Dirofilaria immitis.Parasites & vectors · 2024Article
- A review of moxidectin vs. other macrocyclic lactones for prevention of heartworm disease in dogs with an appraisal of two commercial formulations.Frontiers in veterinary science · 2024Review
- Human gnathostomiasis: A review on the biology of the parasite with special reference on the current therapeutic management.Food and waterborne parasitology · 2023Review
- New paradigms in research on Dirofilaria immitis.Parasites & vectors · 2023Review
- Filarial DAF-12 sense the host serum to resume iL3 development during infection.PLoS pathogens · 2023Article
- Safety of Simparica TrioParasites & vectors · 2023Article
- Onchocerciasis drug development: from preclinical models to humans.Parasitology research · 2021Review
- Effect of sublethal concentrations of the antiparasitic ivermectin on the polychaeta species Hediste diversicolor: biochemical and behavioral responses.Ecotoxicology (London, England) · 2021Article
- Heartworm disease - Overview, intervention, and industry perspective.International journal for parasitology. Drugs and drug resistance · 2021Review
- Tri-Model Therapy: Combining Macrocyclic Lactone, Piperazine Derivative and Herbal Preparation in Treating Humpsore in Cattle.Veterinary sciences · 2021Article
- Whole-genome reference ofCurrent research in parasitology & vector-borne diseases · 2021Article
- Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics.International journal for parasitology. Drugs and drug resistance · 2020Article
- Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes.Journal of extracellular vesicles · 2020Article
- Anthelmintic drug discovery: target identification, screening methods and the role of open science.Beilstein journal of organic chemistry · 2020Review
- Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite.International journal for parasitology. Drugs and drug resistance · 2019Article
- First study of topical selamectin efficacy for treating cats naturally infected with Brugia malayi and Brugia pahangi under field conditions.Parasitology research · 2019Article
- Neurological manifestations in Onchocerca volvulus infection: A review.Brain research bulletin · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The macrocyclic lactones (MLs) are one of the few classes of drug used in the control of the human filarial infections, onchocerciasis and lymphatic filariasis, and the only one used to prevent heartworm disease in dogs and cats. Despite their importance in preventing filarial diseases, the way in which the MLs work against these parasites is unclear. In vitro measurements of nematode motility have revealed a large discrepancy between the maximum plasma concentrations achieved after drug administration and the amounts required to paralyze worms. Recent evidence has shed new light on the likely functions of the ML target, glutamate-gated chloride channels, in filarial nematodes and supports the hypothesis that the rapid clearance of microfilariae that follows treatment involves the host immune system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.