Evidence map›Paper›PMID 27278929›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Lipid microbubbles as a vehicle for targeted drug delivery using focused ultrasound-induced blood-brain barrier opening.

Carlos Sierra, Camilo Acosta, Cherry Chen, Shih-Ying Wu, Maria E Karakatsani, Manuel Bernal, Elisa E Konofagou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

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  10. A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain.Protein science : a publication of the Protein Society · 2023
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  14. A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Carlos Sierra1 Department of Biomedical Engineering, Ultrasound and Elasticity Imaging Laboratory, Columbia University, New York, NY, USA.
Camilo Acosta1 Department of Biomedical Engineering, Ultrasound and Elasticity Imaging Laboratory, Columbia University, New York, NY, USA.
Cherry Chen1 Department of Biomedical Engineering, Ultrasound and Elasticity Imaging Laboratory, Columbia University, New York, NY, USA.
Shih-Ying Wu1 Department of Biomedical Engineering, Ultrasound and Elasticity Imaging Laboratory, Columbia University, New York, NY, USA.
Maria E Karakatsani1 Department of Biomedical Engineering, Ultrasound and Elasticity Imaging Laboratory, Columbia University, New York, NY, USA.
Manuel Bernal2 Department of Microbiology and Immunology, Columbia University, New York, NY, USA.
Elisa E Konofagou1 Department of Biomedical Engineering, Ultrasound and Elasticity Imaging Laboratory, Columbia University, New York, NY, USA.
Columbia University · US

Funding

Assessment of Ultrsound-facilitated Neurotherapeutics in Alzheimer's DiseaseR01AG038961 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2011 to 2020
$5.1M
Optimization of ultrasound-facilitated blood-brain barrier openingR01EB009041 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2008 to 2017
$4.4M
NIA NIH HHS R01 AG038961NIBIB NIH HHS R01 EB009041
6 · The paper itself

Abstract

Focused ultrasound in conjunction with lipid microbubbles has fully demonstrated its ability to induce non-invasive, transient, and reversible blood-brain barrier opening. This study was aimed at testing the feasibility of our lipid-coated microbubbles as a vector for targeted drug delivery in the treatment of central nervous system diseases. These microbubbles were labeled with the fluorophore 5-dodecanoylaminfluorescein. Focused ultrasound targeted mouse brains in vivo in the presence of these microbubbles for trans-blood-brain barrier delivery of 5-dodecanoylaminfluorescein. This new approach, compared to previously studies of our group, where fluorescently labeled dextrans and microbubbles were co-administered, represents an appreciable improvement in safety outcome and targeted drug delivery. This novel technique allows the delivery of 5-dodecanoylaminfluorescein at the region of interest unlike the alternative of systemic exposure. 5-dodecanoylaminfluorescein delivery was assessed by ex vivo fluorescence imaging and by in vivo transcranial passive cavitation detection. Stable and inertial cavitation doses were quantified. The cavitation dose thresholds for estimating, a priori, successful targeted drug delivery were, for the first time, identified with inertial cavitation were concluded to be necessary for successful delivery. The findings presented herein indicate the feasibility and safety of the proposed microbubble-based targeted drug delivery and that, if successful, can be predicted by cavitation detection in vivo.

Indexed as

MicrobubblesAnimalsBlood-Brain BarrierContrast MediaDrug Delivery SystemsFeasibility StudiesFluoresceinsLipidsMagnetic Resonance ImagingMaleMice, Inbred C57BLMicroscopy, ConfocalPharmaceutical VehiclesSonication5-dodecanoylaminofluoresceinContrast MediaFluoresceinsLipidsPharmaceutical VehiclesBlood–brain barriermicroscopyMRItargeted drug deliveryultrasound

Identifiers

PMID27278929
PMCPMC5453447
OpenAlexW2414176894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.