Evidence map›Paper›PMID 27278757›Full record

ArticleNeurochemical research2016

Endothelins Inhibit Osmotic Swelling of Rat Retinal Glial and Bipolar Cells by Activation of Growth Factor Signaling.

Stefanie Vogler, Antje Grosche, Thomas Pannicke, Peter Wiedemann, Andreas Reichenbach, Andreas Bringmann

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Interplay between renal endothelin and purinergic signaling systems.American journal of physiology. Renal physiology · 2017
    Review
  2. Implication of VEGF and aquaporin 4 mediating Müller cell swelling to diabetic retinal edema.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Stefanie VoglerPaul Flechsig Institute of Brain Research, University of Leipzig, 04103, Leipzig, Germany.
Antje GroscheInstitute of Human Genetics, University of Regensburg, 93053, Regensburg, Germany.
Thomas PannickePaul Flechsig Institute of Brain Research, University of Leipzig, 04103, Leipzig, Germany.
Peter WiedemannDepartment of Ophthalmology, Eye Hospital, University of Leipzig, Liebigstrasse 10-14, 04103, Leipzig, Germany.
Andreas ReichenbachPaul Flechsig Institute of Brain Research, University of Leipzig, 04103, Leipzig, Germany.
Andreas BringmannDepartment of Ophthalmology, Eye Hospital, University of Leipzig, Liebigstrasse 10-14, 04103, Leipzig, Germany. bria@medizin.uni-leipzig.de.
Leipzig University · DEUniversity Hospital Leipzig · DEUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water accumulation in retinal glial (Müller) and neuronal cells resulting in cellular swelling contributes to the development of retinal edema and neurodegeneration. Here, we show that endothelin-1 (ET-1) dose-dependently inhibits the hypoosmotic swelling of Müller cells in freshly isolated retinal slices of control and diabetic rats, with a maximal inhibition at 100 nM. Osmotic Müller cell swelling was also inhibited by ET-2. The effect of ET-1 was mediated by activation of ET

Indexed as

AnimalsCell SizeDiabetes Mellitus, ExperimentalEndothelinsEpendymoglial CellsIntercellular Signaling Peptides and ProteinsNeurogliaOsmosisOsmotic PressureRats, Long-EvansRats, Sprague-DawleyRetinaSignal TransductionEndothelinsIntercellular Signaling Peptides and ProteinsBipolar cellCell swellingDiabetic retinopathyEndothelinMüller cellRetina

Identifiers

PMID27278757
OpenAlexW2410685880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.