ArticleBMC infectious diseases2016
A prospective longitudinal study of tuberculosis among household contacts of smear-positive tuberculosis cases in Lima, Peru.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Risk factors for infectiousness of patients with tuberculosis: a systematic review and meta-analysis.Epidemiology and infection · 2018Pooled it
- Article
- The association of household conditions with the development of active pulmonary TB among in households with a previous TB patient: a community-based case-control study.BMC pulmonary medicine · 2026Article
- Reappraising TB preventive treatment in India: programmatic and ethical implications of subclinical tuberculosis in household contacts.The Lancet regional health. Southeast Asia · 2026Review
- Assessing Infectiousness and the Impact of Effective Treatment to Guide Isolation Recommendations for People With Pulmonary Tuberculosis.The Journal of infectious diseases · 2025Review
- Timing and predictors of disease incidence among named contacts of reported tuberculosis patients in a low incidence setting.PloS one · 2025Article
- Comparison of the yield of two tuberculosis screening approaches among household contacts in a community setting of Silti Zone, Central Ethiopia: a prospective cohort study.BMC pulmonary medicine · 2024Article
- Incidence and risk factors of tuberculosis among 420 854 household contacts of patients with tuberculosis in the 100 Million Brazilian Cohort (2004-18): a cohort study.The Lancet. Infectious diseases · 2024Article
- Yield of Tuberculosis Contact Screening and Predictors of Contact Tuberculosis Diagnosis in Bungoma County Hospital, Kenya.International journal of health sciences and research · 2023Article
- Assessment of Smear-Positive Pulmonary Tuberculosis and Associated Factors among Patients Visiting Health Facilities of Gedeo Zone, Southern Ethiopia: A Cross-Sectional Study.Tuberculosis research and treatment · 2023Article
- Drug susceptibility patterns of Mycobacterium tuberculosis from adults with multidrug-resistant tuberculosis and implications for a household contact preventive therapy trial.BMC infectious diseases · 2021Article
- Contact evaluation and isoniazid preventive therapy among close and household contacts of tuberculosis patients in Lima, Peru: an analysis of routine data.Tropical medicine & international health : TM & IH · 2020Article
- Baseline Assessment of Risk Factors of Presumptive Tuberculosis among under Five Children Living with an Index Client under Treatment in Mbale District, Eastern Uganda.Microbiology research journal international · 2020Article
- [Epidemiological profile of extensively drug-resistant tuberculosis in Peru, 2013-2015Perfil epidemiológico da tuberculose extremamente resistente no Peru, 2013-2015].Revista panamericana de salud publica = Pan American journal of public health · 2020Article
- Prevalence and Associated Factors of Tuberculosis among Adult Household Contacts of Smear Positive Pulmonary Tuberculosis Patients Treated in Public Health Facilities of Haramaya District, Oromia Region, Eastern Ethiopia.Tuberculosis research and treatment · 2020Article
- The Implementation of Early Detection in Tuberculosis Contact Investigation to Improve Case Finding.Journal of epidemiology and global health · 2019Article
- Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003).The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018Article
- Knowledge about tuberculosis and infection prevention behavior: A nine city longitudinal study from India.PloS one · 2018Article
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundHousehold contacts (HHCs) of TB cases are at increased risk for TB disease compared to the general population but the risk may be modified by individual or household factors. We conducted a study to determine incident TB among HHCs over two years after exposure and to identify individual and household level risk factors.
methodsAdults newly diagnosed with a first episode of smear-positive pulmonary TB (index cases) between March 2010 and December 2011 in eastern Lima, were interviewed to identify their HHC and household characteristics. TB registers were reviewed for up to two years after the index case diagnosis and house visits were made to ascertain TB cases among HHC. The TB incidence rate ratio among HHCs as a function of risk factors was determined using generalized linear mixed models.
resultsThe 1178 index cases reported 5466 HHCs. In 402/1178 (34.1 %) households, at least one HHC had experienced a TB episode ever. The TB incidence among HHCs was 1918 (95%CI 1669-2194) per 100,000 person-years overall, and was 2392 (95%CI 2005-2833) and 1435 (95%CI 1139-1787) per 100,000 person-years in the first and second year, respectively. Incident TB occurred more than six months following the index case's TB diagnosis in 121/205 (59.0 %) HHCs. In HHCs, bacillary load and time between symptoms and treatment initiation in the index case, as well as the relationship to the index case and the sex of the HHC all had a significant association with TB incidence in HHCs.
conclusionsIncidence of TB among HHCs was more than ten times higher than in the general population. Certain HHC and households were at higher risk of TB, we recommend studies to compare HHC investigation to households at highest risk versus current practice, in terms of efficiency.
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