Evidence map›Paper›PMID 27278522›Full record

ArticleEuropean journal of applied physiology2016

Aortic augmentation index in endurance athletes: a role for cardiorespiratory fitness.

Joshua Denham, Nicholas J Brown, Maciej Tomaszewski, Bryan Williams, Brendan J O'Brien, Fadi J Charchar

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Article in European journal of applied physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  12. Vascular health determinants in children.Cardiovascular diagnosis and therapy · 2019
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Joshua DenhamSchool of Science and Technology, University of New England, Armidale, NSW, 2351, Australia. jdenham2@une.edu.au.ORCID http://orcid.org/0000-0001-5804-4960
Nicholas J BrownFaculty of Health, Federation University Australia, University Drive, Mt Helen, VIC, Australia.
Maciej TomaszewskiDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Bryan WilliamsInstitute of Cardiovascular Sciences University College London (UCL) and National Institute for Health Research (NIHR) UCL/UCL Hospitals Biomedical Research Centre, London, UK.
Brendan J O'BrienFaculty of Health, Federation University Australia, University Drive, Mt Helen, VIC, Australia.
Fadi J CharcharFaculty of Science and Technology, Federation University Australia, University Drive, Mt Helen, VIC, Australia.

Funding

Medical Research Council MC_PC_13090
6 · The paper itself

Abstract

purposeEndurance exercise improves cardiovascular health and reduces mortality risk. Augmentation index (AIx) reflects adverse loading exerted on the heart and large arteries and predicts future cardiovascular disease. The purpose of this study was to establish whether endurance athletes possess lower AIx and aortic blood pressure compared to healthy controls, and to determine the association between AIx and cardiorespiratory fitness.

methodsForty-six endurance athletes and 43 healthy controls underwent central BP and AIx measurements by non-invasive applanation tonometry before a maximal exercise test. Peak oxygen uptake ([Formula: see text]) was assessed by pulmonary analysis.

resultsRelative to controls, athletes had significantly lower brachial diastolic blood pressure (BP, -4.8 mmHg, p < 0.01), central systolic BP (-3.5 mmHg, p = 0.07), and AIx at a heart rate of 75 beats min(-1) (AIx@75, -11.9 %, p < 0.001). No AIx@75 differences were observed between athletes and controls when adjusted for age and [Formula: see text] [athletes vs controls mean (%) ± SE: -6.9 ± 2.2 vs -5.7 ± 2.3, p = 0.76]. Relative to men with low [Formula: see text], those with moderate and high [Formula: see text] had lower age-adjusted AIx@75 (p < 0.001). In women, those with high [Formula: see text] had lower AIx@75 than those with low and moderate [Formula: see text] (p < 0.01).

conclusionsThe lower AIx@75 in endurance athletes is partly mediated by [Formula: see text]. While an inverse relationship between AIx@75 and [Formula: see text] was found in men, women with the highest [Formula: see text] possessed lowest AIx@75 compared to females with moderate or poor cardiorespiratory fitness. We recommend aerobic training aimed at achieving a minimum [Formula: see text] of 45 ml kg(-1) min(-1) to decrease the risk of future cardiovascular events and all-cause mortality.

Indexed as

AdolescentAdultAortaArterial PressureAthletic PerformanceCardiorespiratory FitnessFemaleHumansMaleMiddle AgedOxygen ConsumptionPhysical EnduranceReproducibility of ResultsSensitivity and SpecificitySportsVascular StiffnessArterial stiffnessCardiovascular healthCentral blood pressureVO2max

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.