ArticleBMC infectious diseases2016
Soil-transmitted helminth infections and leprosy: a cross-sectional study of the association between two major neglected tropical diseases in Indonesia.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Mycobacterium leprae infection, Hansen's disease, and helminth infections: A cross-sectional study in southeastern Brazil.PLoS neglected tropical diseases · 2026Article
- Seroprevalence ofThe Lancet regional health. Southeast Asia · 2026Article
- Serum levels of Interleukin-10, Interleukin-6, and leptin in patients with Mycobacterium leprae-Helminth Co-Infections.BMC infectious diseases · 2025Observational
- Estimation of Serum Vitamin D Levels and Helminthic Coinfection in Patients with Type 2 Lepra Reactions and its Correlation with Severity of Type 2 Reactions: A Cross-Sectional Study.Indian dermatology online journal · 2025Article
- Serological Evidence of Soil-Transmitted Helminth Infections as a Potential Risk for Severity in Leprosy Patients.Tropical medicine & international health : TM & IH · 2025Article
- Article
- Investigating the role of soil-transmitted helminth infections in the development of leprosy in endemic regions.Frontiers in immunology · 2025Article
- Spatial associations of Hansen's disease and schistosomiasis in endemic regions of Minas Gerais, Brazil.PLoS neglected tropical diseases · 2024Article
- Bacterial, fungal and parasitic co-infections in leprosy: A scoping review.PLoS neglected tropical diseases · 2023Article
- Leprosy and cutaneous leishmaniasis affecting the same individuals: A retrospective cohort analysis in a hyperendemic area in Brazil.PLoS neglected tropical diseases · 2021Article
- Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.PLoS neglected tropical diseases · 2021Article
- Serological evidence of Toxoplasma gondii infection as potential risk for the development of lepromatous leprosy in an endemic area for both neglected tropical diseases in Brazil.Infectious diseases of poverty · 2020Article
- The Burden of Helminth Coinfections and Micronutrient Deficiencies in Patients with and without Leprosy Reactions: A Pilot Study in Minas Gerais, Brazil.The American journal of tropical medicine and hygiene · 2019Article
- The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens.Frontiers in immunology · 2018Review
- Opening a Can of Worms: Leprosy Reactions and Complicit Soil-Transmitted Helminths.EBioMedicine · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical spectrum of leprosy is dependent on the host immune response against Mycobacterium leprae or the newly discovered Mycobacterium lepromatosis antigen. Helminth infections have been shown to affect the development of several diseases through immune regulation and thus may play a role in the clinical manifestations of leprosy and leprosy reactions. The purpose of this study is to determine the proportion of helminth infections in leprosy and its association with the type of leprosy and type 2 leprosy reaction (T2R).
methodsHistory or episode of T2R was obtained and direct smear, formalin-ether sedimentation technique, and Kato-Katz smear were performed on 20 paucibacillary (PB) and 61 multibacillary (MB) leprosy participants.
resultsThere are more helminth-positive participants in MB leprosy compared to PB (11/61 versus 0/20, p = 0.034) and in T2R participants compared to non-T2R (8/31 versus 3/50, p = 0.018).
conclusionsOur results suggest that soil-transmitted helminth infections may have a role in the progression to a more severe type of leprosy, as well as the occurrence of T2R. These findings could serve as a fundamental base for clinicians to perform parasitological feces examination in patients who have MB leprosy and severe recurrent reactions to rule out the possibility of helminth infection. Further secondary confirmation of findings are needed to support these conclusions.
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