Evidence map›Paper›PMID 27278377›Full record

ArticleNeuroradiology2016

Kinetic DTI of the cervical spine: diffusivity changes in healthy subjects.

Félix P Kuhn, Antoine Feydy, Nathalie Launay, Marie-Martine Lefevre-Colau, Serge Poiraudeau, Sébastien Laporte, Marc A Maier, Pavel Lindberg

Abstract read
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In one paragraph

Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. The evaluation on neural status of cervical spinal cord in normal and Hirayama disease using diffusion tensor imaging.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Félix P KuhnService de Radiologie B, APHP, Centre Hospitalier Universitaire Cochin, Faculté de Médecine, Université Paris Descartes, 27 rue du Fbg St Jacques, 75679, Paris, France. Felix.Kuhn@usz.ch.
Antoine FeydyService de Radiologie B, APHP, Centre Hospitalier Universitaire Cochin, Faculté de Médecine, Université Paris Descartes, 27 rue du Fbg St Jacques, 75679, Paris, France.
Nathalie LaunayService de Radiologie B, APHP, Centre Hospitalier Universitaire Cochin, Faculté de Médecine, Université Paris Descartes, 27 rue du Fbg St Jacques, 75679, Paris, France.
Marie-Martine Lefevre-ColauINSERM, U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidémiologie clinique appliquées aux maladies ostéo-articulaires (Ecamo), Université Paris Descartes, Paris, France.
Serge PoiraudeauINSERM, U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidémiologie clinique appliquées aux maladies ostéo-articulaires (Ecamo), Université Paris Descartes, Paris, France.
Sébastien LaporteLaboratoire de Biomécanique, Ecole Nationale Supérieure d'Arts et Métiers, Paris, France.
Marc A MaierCentre de Psychiatrie et Neurosciences, INSERM U894, Paris, France.
Pavel LindbergCentre de Psychiatrie et Neurosciences, INSERM U894, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe study aims to assess the influence of neck extension on water diffusivity within the cervical spinal cord.

methodsIRB approved the study in 22 healthy volunteers. All subjects underwent anatomical MR and diffusion tensor imaging (DTI) at 1.5 T. The cervical cord was imaged in neutral (standard) position and extension. Segmental vertebral rotations were analyzed on sagittal T2-weighted images using the SpineView® software. Spinal cord diffusivity was measured in cross-sectional regions of interests at multiple levels (C1-C5).

resultsAs a result of non-adapted coil geometry for spinal extension, 10 subjects had to be excluded. Image quality of the remaining 12 subjects was good without any deteriorating artifacts. Quantitative measurements of vertebral rotation angles and diffusion parameters showed good intra-rater reliability (ICC = 0.84-0.99). DTI during neck extension revealed significantly decreased fractional anisotropy (FA) and increased radial diffusivity (RD) at the C3 level and increased apparent diffusion coefficients (ADC) at the C3 and C4 levels (p < 0.01 Bonferroni corrected). The C3/C4 level corresponded to the maximal absolute change in segmental vertebral rotation between the two positions. The increase in RD correlated positively with the degree of global extension, i.e., the summed vertebral rotation angle between C1 and C5 (R = 0.77, p = 0.006).

conclusionOur preliminary results suggest that DTI can quantify changes in water diffusivity during cervical spine extension. The maximal differences in segmental vertebral rotation corresponded to the levels with significant changes in diffusivity (C3/C4). Consequently, kinetic DTI measurements may open new perspectives in the assessment of neural tissue under biomechanical constraints.

Indexed as

AdultBody WaterCervical CordCervical VertebraeDiffusionDiffusion Tensor ImagingFemaleHumansImage Interpretation, Computer-AssistedKineticsMaleMiddle AgedPilot ProjectsRange of Motion, ArticularReference ValuesReproducibility of ResultsBiomechanicsCervical spineDiffusion tensor imaging (DTI)Diffusion-weighted imaging (DWI)

Identifiers

PMID27278377

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.