ReviewCurrent hypertension reports2016
Obstructive Sleep Apnoea and Hypertension: the Role of the Central Nervous System.
Review in Current hypertension reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A Systematic Review of Publications on the Associations Between Sleep Architecture and Arterial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2023Pooled it
- Self-reported sleep characteristics are linked to type 2 diabetes in middle-aged and elderly individuals: a cross-sectional study based on NHANES.Irish journal of medical science · 2023Article
- Baroreflex sensitivity during rest and pressor challenges in obstructive sleep apnea patients with and without CPAP.Sleep medicine · 2022Article
- Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.JACC. Basic to translational science · 2022Review
- The Sympathetic Nervous System in Hypertension: Roadmap Update of a Long Journey.American journal of hypertension · 2021Article
- Functional organization of the insula in men and women with obstructive sleep apnea during Valsalva.Sleep · 2021Article
- Moderating Effect of BMI on the Relationship Between Sympathetic Activation and Blood Pressure in Males with Obstructive Sleep Apnea.Nature and science of sleep · 2021Article
- Is the Brain an Early or Late Component of Essential Hypertension?American journal of hypertension · 2020Review
- Relationships between cardiometabolic disorders and obstructive sleep apnea: Implications for cardiovascular disease risk.Journal of clinical hypertension (Greenwich, Conn.) · 2019Observational
- Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.Scientific reports · 2018Article
- Joint interaction effect of metabolic syndrome and obstructive sleep apnea on hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Erythropoietin, a putative neurotransmitter during hypoxia, is produced in RVLM neurons and activates them in neonatal Wistar rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Clinical and prognostic significance of a reverse dipping pattern on ambulatory monitoring: An updated review.Journal of clinical hypertension (Greenwich, Conn.) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewObstructive sleep apnoea (OSA) is associated with both nocturnal and daytime hypertensions which increase cardiovascular morbidity and mortality. It is thought that the repeated episodes of hypoxia and hypercapnia during nocturnal airway obstructions that characterise OSA result in increased sympathetic drive that persists during wakefulness. Although the underlying mechanisms responsible for this hypertension remain to be elucidated, several neural and humoral mechanisms have been proposed and recent evidence suggesting changes in the central nervous system may play a significant role. The purpose of this review is to explore recent evidence of central changes associated with elevated sympathetic drive in individuals with OSA. RECENT
findingsRecent human brain imaging investigations and, in particular, combined microneurography recording of resting sympathetic activity with high-resolution functional magnetic resonance imaging have provided some important insights into changes in brain function and anatomy associated with resting sympathetic activity. Functional and anatomical changes occur in OSA, including in regions of the brainstem circuitry known to be responsible for setting resting sympathetic activity. Furthermore, these changes are reversed following continuous positive airway treatment in concert with reductions in resting sympathetic drive. These resent findings suggest that the central changes may contribute significantly to the hypertension associated with OSA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.