Evidence map›Paper›PMID 27278063›Full record

Observational studyJournal of neurology2016

Effect of botulinum toxin treatment on quality of life in patients with isolated lingual dystonia and oromandibular dystonia affecting the tongue.

Laura Nastasi, Giovanni Mostile, Alessandra Nicoletti, Mario Zappia, Ester Reggio, Santiago Catania

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pilot Single-Blind Trial of AbobotulinumtoxinA in Oromandibular Dystonia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Observational
  18. Longitudinal studies of botulinum toxin in cervical dystonia: Why do patients discontinue therapy?Toxicon : official journal of the International Society on Toxinology · 2018
    Review
  19. Botulinum Toxin Treatment of Movement Disorders.Current treatment options in neurology · 2018
    Review
  20. Botulinum Neurotoxin, an Example of Successful Translational Research.Clinical pharmacology and translational medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Laura NastasiDepartment of Clinical Neurophysiology (Box141), National Hospital of Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK.
Giovanni MostileDepartment GF Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy.
Alessandra NicolettiDepartment GF Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy.
Mario ZappiaDepartment GF Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy.
Ester ReggioDepartment GF Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy.
Santiago CataniaDepartment of Clinical Neurophysiology (Box141), National Hospital of Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK. santi.catania@uclh.nhs.uk.
University of Catania · ITNational Hospital for Neurology and Neurosurgery · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to investigate the impact of botulinum toxin (BoNT) treatment on the quality of life (QoL) for patients with prominent lingual dystonia (LD) using a disease-specific questionnaire, the oromandibular dystonia questionnaire-25 (OMDQ-25). This is a prospective, observational study of a cohort of 30 patients treated with BoNT injections for LD, with or without concurrent jaw dystonia. Primary efficacy outcome was the absolute difference between total OMDQ-25 baseline score and total OMDQ-25 scores 4 and 8 weeks after the treatment. Safety outcome was the occurrence of adverse effects. The mean total OMDQ-25 baseline score was 46.8 ± 17.8. After BoNT treatment, there was a significant reduction in the mean total OMDQ-25 score at 4 weeks (38.2 ± 17.6; p = 0.004), as well as at 8 weeks (39.6 ± 18.1; p = 0.008). At the multiple regression analysis, a jaw deviation pattern (JDD) and high questionnaire baseline total score were detected as predictors of a better outcome, whilst associated jaw tremor was a predictor of poor outcome. In patients with JDD, jaw-opening muscles were more frequently injected and genioglossus less frequently than in patients without JDD. No major adverse events were detected. A consistent and measurable improvement in QoL, with good safety and tolerability, can be achieved in patients with prominent LD by injecting BoNT into genioglossus and/or other muscles of the oromandibular region.

Indexed as

Botulinum Toxins, Type ADystoniaFemaleFollow-Up StudiesHumansInjections, IntramuscularMaleMandibular DiseasesMiddle AgedNeuromuscular AgentsPrognosisProspective StudiesQuality of LifeSurveys and QuestionnairesTongue DiseasesTreatment OutcomeBotulinum Toxins, Type ANeuromuscular AgentsBotulinum toxinJaw tremorLingual dystoniaOromandibular dystoniaQuality of life

Identifiers

PMID27278063
OpenAlexW2419107899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.