Evidence map›Paper›PMID 27277868›Full record

ReviewNature reviews. Neuroscience2016

Time to connect: bringing social context into addiction neuroscience.

Markus Heilig, David H Epstein, Michael A Nader, Yavin Shaham

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Acute effects of alcohol on social and personal decision making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. The (un-)Social Brain in Isolation.Physiological research · 2025
    Review
  19. Geographical narcissism and Ontario's opioid crisis.Canadian journal of public health = Revue canadienne de sante publique · 2025
    Article
  20. Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Markus HeiligCenter for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine (IKE), Linköping University, SE-581 83 Linköping, Sweden.
David H EpsteinIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21044, USA.
Michael A NaderDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Yavin ShahamIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21044, USA.

Funding

Neurobiology Of Relapse To Opiate and Psychostimulant DrugsZIADA000434 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SHAHAM, YAVIN · 2009 to 2025
$39.8M
Real-Time Assessment of Drug Use, Along with Mental States and EnvironmentsZIADA000499 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI EPSTEIN, DAVID · 2009 to 2025
$19.9M
Mechanisms Mediating Cocaine Abuse in Socially Housed Female and Male MonkeysR01DA017763 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael A Nader · 2004 to 2026
$9.8M
Prevention of Relapse in AddictionZIADA000536 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI PRESTON, KENZIE · 2009 to 2018
$9.5M
Evaluation Of Treatments Of Opioid And Cocaine DependenceZIADA000175 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI PRESTON, KENZIE · 2009 to 2016
$7.4M
Social Stress: Vulnerability to Cocaine Abuse in MonkeysR37DA010584 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NADER, MICHAEL A · 2005 to 2014
$4.8M
SOCIAL STRESS--VULNERABILITY TO COCAINE ABUSE IN MONKEYSR01DA010584 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NADER, MICHAEL A · 1996 to 2004
$1.9M
Intramural NIH HHS Z99 DA999999NIDA NIH HHS R01 DA010584NIDA NIH HHS R01 DA017763NIDA NIH HHS R37 DA010584
6 · The paper itself

Abstract

Research on the neural substrates of drug reward, withdrawal and relapse has yet to be translated into significant advances in the treatment of addiction. One potential reason is that this research has not captured a common feature of human addiction: progressive social exclusion and marginalization. We propose that research aimed at understanding the neural mechanisms that link these processes to drug seeking and drug taking would help to make addiction neuroscience research more clinically relevant.

Indexed as

RewardSocial EnvironmentAnimalsBehavior, AddictiveBrainHumansNeural PathwaysSubstance-Related Disorders

Identifiers

PMID27277868
PMCPMC5523661

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.