Evidence map›Paper›PMID 27277011›Full record

ArticleScientific reports2016

Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring.

Sarah J Glastras, Michael Tsang, Rachel Teh, Hui Chen, Rachel T McGrath, Amgad A Zaky, Carol A Pollock, Sonia Saad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  10. The First Thousand Days: Kidney Health and Beyond.Healthcare (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sarah J GlastrasDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Michael TsangSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Australia.
Rachel TehDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Hui ChenSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Australia.
Rachel T McGrathDepartment of Diabetes, Endocrinology and Metabolism, Royal North Shore Hospital, St Leonards, Australia.
Amgad A ZakyDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Carol A PollockDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
Sonia SaadDepartment of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
University of Sydney · AURoyal North Shore Hospital · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal obesity is known to increase the risk of obesity and diabetes in offspring. Though diabetes is a key risk factor for the development of chronic kidney disease (CKD), the relationship between maternal obesity and CKD has not been clearly defined. In this study, a mouse model of maternal obesity was employed to determine the impact of maternal obesity on development of diabetic nephropathy in offspring. Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow diet. At postnatal Week 8, offspring were randomly administered low dose streptozotocin (STZ, 55 mg/kg/day for five days) to induce diabetes. Assessment of renal damage took place at postnatal Week 32. We found that offspring of obese mothers had increased renal fibrosis, inflammation and oxidative stress. Importantly, offspring exposed to maternal obesity had increased susceptibility to renal damage when an additional insult, such as STZ-induced diabetes, was imposed. Specifically, renal inflammation and oxidative stress induced by diabetes was augmented by maternal obesity. Our findings suggest that developmental programming induced by maternal obesity has implications for renal health in offspring. Maternal obesity should be considered a risk factor for CKD.

Indexed as

AnimalsBiomarkersDiabetes Mellitus, ExperimentalDiabetic NephropathiesDiet, High-FatDisease Models, AnimalFemaleHumansKidney Function TestsMaleMaternal Nutritional Physiological PhenomenaMiceMice, Inbred C57BLObesityOxidative StressPregnancyBiomarkersStreptozocin

Identifiers

PMID27277011
PMCPMC4899795
OpenAlexW2411469380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.