ReviewChemical Society reviews2016
(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.
Review in Chemical Society reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Carbon-11 Production: Communication, Operations, Maintenance, Troubleshooting, and Analysis for Maintaining High-Grade Bombardment and Provisions of [Molecules (Basel, Switzerland) · 2026Article
- Organic Fluorophores Conjugated with Pyridinium Acceptor: A Review on Design, Synthesis, and Application in Mitochondrial Imaging.Current pharmaceutical design · 2026Review
- Automated Manufacturing of Carbon-11 Radiopharmaceuticals Using Cassette-Based Radiosynthesizers.Journal of labelled compounds & radiopharmaceuticals · 2025Review
- Ionic Liquid Aided [ChemistryOpen · 2025Article
- Radiolabeling and Preliminary In Vivo Evaluation of the Candidate CCR2 Targeting PET Radioligand [Pharmaceuticals (Basel, Switzerland) · 2025Article
- Photo- and Cu-MediatedOrganic letters · 2024Article
- Radiochemistry for positron emission tomography.Nature communications · 2023Review
- Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies.Molecules (Basel, Switzerland) · 2023Review
- Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- Ring-opening of non-activated aziridines with [RSC advances · 2022Article
- Broad Scope and High-Yield Access to Unsymmetrical Acyclic [Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Radiosynthesis of [Frontiers in nuclear medicine · 2021Article
- Fully Automated Radiosynthesis of [ACS medicinal chemistry letters · 2020Article
- Imaging Biotin Trafficking In Vivo with Positron Emission Tomography.Journal of medicinal chemistry · 2020Article
- Rapid and Efficient Synthesis of [ACS omega · 2020Article
- Transition-Metal-Free Carbon Isotope Exchange of Phenyl Acetic Acids.Angewandte Chemie (International ed. in English) · 2020Article
- Synthesis and pharmacokinetic study of aBioorganic & medicinal chemistry letters · 2020Article
- [Angewandte Chemie (International ed. in English) · 2020Article
- Copper(I)-MediatedACS omega · 2020Article
- Synthesis and evaluation of 6-(Bioorganic & medicinal chemistry letters · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The positron-emitting radionuclide carbon-11 ((11)C, t1/2 = 20.3 min) possesses the unique potential for radiolabeling of any biological, naturally occurring, or synthetic organic molecule for in vivo positron emission tomography (PET) imaging. Carbon-11 is most often incorporated into small molecules by methylation of alcohol, thiol, amine or carboxylic acid precursors using [(11)C]methyl iodide or [(11)C]methyl triflate (generated from [(11)C]carbon dioxide or [(11)C]methane). Consequently, small molecules that lack an easily substituted (11)C-methyl group are often considered to have non-obvious strategies for radiolabeling and require a more customized approach. [(11)C]Carbon dioxide itself, [(11)C]carbon monoxide, [(11)C]cyanide, and [(11)C]phosgene represent alternative reactants to enable (11)C-carbonylation. Methodologies developed for preparation of (11)C-carbonyl groups have had a tremendous impact on the development of novel PET tracers and provided key tools for clinical research. (11)C-Carbonyl radiopharmaceuticals based on labeled carboxylic acids, amides, carbamates and ureas now account for a substantial number of important imaging agents that have seen translation to higher species and clinical research of previously inaccessible targets, which is a testament to the creativity, utility and practicality of the underlying radiochemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.