ArticlePloS one2016
207-nm UV Light-A Promising Tool for Safe Low-Cost Reduction of Surgical Site Infections. II: In-Vivo Safety Studies.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 172 citations in OpenAlex.
- Environmental Disinfection in Long-Term Care Facilities-A Scoping Review.Microorganisms · 2026Review
- The Efficacy of UV-C Disinfection in Decreasing Hospital-Acquired Infections and Bioburden in an Adult Burns Service.European burn journal · 2026Article
- Novel use of far UV-C light as a surface disinfectant in the poultry industry: trials on broiler farms show reduced bacterial burden in poultry anterooms and on wellington boots.Poultry science and management · 2026Article
- Dermatological effects of acute and long-term UV-C exposure: an in vivo study using a portable mercury lamp.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- UV radiation at 222, 254, and 282 nm inhibits sporulation and suppresses infectivity ofMicrobiology spectrum · 2025Article
- Comparative study between UVB 313 nm, UVC 254 nm, and far UVC 222 nm light on the aging of polyamide 66.Heliyon · 2024Article
- PRSS3/mesotrypsin as a putative regulator of the biophysical characteristics of epidermal keratinocytes in superficial layers.Scientific reports · 2024Article
- Feasibility analysis of inactivating influenza A(H1N1) virus using UVC robot in classroom environment.Heliyon · 2024Article
- The new 222-nm far ultraviolet-C lowers bacterial contamination to endoscopists during esophagogastroduodenoscopy.DEN open · 2024Article
- 222 nm far-UVC light markedly reduces the level of infectious airborne virus in an occupied room.Scientific reports · 2024Article
- Germicidal efficacy of continuous and pulsed ultraviolet-C radiation on pathogen models and SARS-CoV-2.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024Article
- Article
- Fluence-dependent degradation of fibrillar type I collagen by 222 nm far-UVC radiation.PloS one · 2024Article
- Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection.Viruses · 2023Article
- Structural and biological engineering of 3D hydrogels for wound healing.Bioactive materials · 2023Review
- Spatial immunization to abate disease spreading in transportation hubs.Nature communications · 2023Article
- Pollution free UV-C radiation to mitigate COVID-19 transmission.Gondwana research : international geoscience journal · 2023Article
- Article
- No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long-Term (66 week) Chronic Exposure to 222-nm Far-UVC Radiation.Photochemistry and photobiology · 2023Article
- The Paradoxical Role of far-Ultraviolet C (far-UVC) in Inactivation of SARS-CoV-2: The Issue of Droplet Size.Journal of biomedical physics & engineering · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundUVC light generated by conventional germicidal lamps is a well-established anti-microbial modality, effective against both bacteria and viruses. However, it is a human health hazard, being both carcinogenic and cataractogenic. Earlier studies showed that single-wavelength far-UVC light (207 nm) generated by excimer lamps kills bacteria without apparent harm to human skin tissue in vitro. The biophysical explanation is that, due to its extremely short range in biological material, 207 nm UV light cannot penetrate the human stratum corneum (the outer dead-cell skin layer, thickness 5-20 μm) nor even the cytoplasm of individual human cells. By contrast, 207 nm UV light can penetrate bacteria and viruses because these cells are physically much smaller.
aimsTo test the biophysically-based hypothesis that 207 nm UV light is not cytotoxic to exposed mammalian skin in vivo.
methodsHairless mice were exposed to a bactericidal UV fluence of 157 mJ/cm2 delivered by a filtered Kr-Br excimer lamp producing monoenergetic 207-nm UV light, or delivered by a conventional 254-nm UV germicidal lamp. Sham irradiations constituted the negative control. Eight relevant cellular and molecular damage endpoints including epidermal hyperplasia, pre-mutagenic UV-associated DNA lesions, skin inflammation, and normal cell proliferation and differentiation were evaluated in mice dorsal skin harvested 48 h after UV exposure.
resultsWhile conventional germicidal UV (254 nm) exposure produced significant effects for all the studied skin damage endpoints, the same fluence of 207 nm UV light produced results that were not statistically distinguishable from the zero exposure controls.
conclusionsAs predicted by biophysical considerations and in agreement with earlier in vitro studies, 207-nm light does not appear to be significantly cytotoxic to mouse skin. These results suggest that excimer-based far-UVC light could potentially be used for its anti-microbial properties, but without the associated hazards to skin of conventional germicidal UV lamps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.