Evidence map›Paper›PMID 27275836›Full record

ReviewJournal of clinical medicine2016

Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology.

Reza Golestani, Jae-Joon Jung, Mehran M Sadeghi

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Scientific reports · 2017
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Reza GolestaniCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT 06511, USA. reza.golestani@yale.edu.
Jae-Joon JungCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT 06511, USA. jaejoon.jung@yale.edu.
Mehran M SadeghiCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale School of Medicine, New Haven, CT 06511, USA. mehran.sadeghi@yale.edu.

Funding

Imaging protease activation in calcific aortic valve diseaseR01HL114703 · NHLBI · YALE UNIVERSITY · PI SADEGHI, MEHRAN M · 2012 to 2016
$2.0M
Macrophage elastase and its imaging in vascular inflammation and remodelingR01HL112992 · NHLBI · YALE UNIVERSITY · PI SADEGHI, MEHRAN M · 2013 to 2016
$2.0M
Molecular Imaging of Protease Activation in AneurysmI01BX001750 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI SADEGHI, MEHRAN M · 2013 to 2016
–
BLRD VA I01 BX001750NHLBI NIH HHS R01 HL112992NHLBI NIH HHS R01 HL114703
6 · The paper itself

Abstract

Angiogenesis and vascular remodeling are involved in a wide array of cardiovascular diseases, from myocardial ischemia and peripheral arterial disease, to atherosclerosis and aortic aneurysm. Molecular imaging techniques to detect and quantify key molecular and cellular players in angiogenesis and vascular remodeling (e.g., vascular endothelial growth factor and its receptors, αvβ3 integrin, and matrix metalloproteinases) can advance vascular biology research and serve as clinical tools for early diagnosis, risk stratification, and selection of patients who would benefit most from therapeutic interventions. To target these key mediators, a number of molecular imaging techniques have been developed and evaluated in animal models of angiogenesis and vascular remodeling. This review of the state of the art molecular imaging of angiogenesis and vascular (and valvular) remodeling, will focus mostly on nuclear imaging techniques (positron emission tomography and single photon emission tomography) that offer high potential for clinical translation.

Indexed as

angiogenesisinflammationmatrix metalloproteinasemolecular imagingvascular endothelial growth factorvascular remodelingαvβ3 integrin

Identifiers

PMID27275836
PMCPMC4929412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.