ArticleToxins2016
Evaluation of the Toxicity and Toxicokinetics of Cereulide from an Emetic Bacillus cereus Strain of Milk Origin.
Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Rapid risk assessment on acute reference dose (ARfD) of cereulide in infants and information on acute consumption of infant formulae.EFSA journal. European Food Safety Authority · 2026Article
- Article
- Prevalence of antibiotic resistance genes its association with microbiota in raw milk of northwest Xinjiang.Frontiers in microbiology · 2025Article
- Evaluating the Safety ofMicroorganisms · 2024Article
- Toxigenic diversity ofFood science and biotechnology · 2024Article
- Brain circuits for retching-like behavior.National science review · 2024Article
- Validation of a Targeted LC-MS/MS Method for Cereulide and Application in Food and Faeces.Toxins · 2023Article
- Prevalence, Toxin Genes, and Antibiotic Resistance Profiles ofIndian journal of microbiology · 2023Article
- Characterization of the Toxigenic Potential ofFoods (Basel, Switzerland) · 2023Article
- High Genetic Diversity and Virulence Potential inFoods (Basel, Switzerland) · 2023Article
- Post-Cooking Growth and Survival ofFoods (Basel, Switzerland) · 2023Article
- Prevalence and characterization of toxigenicFood science and biotechnology · 2022Article
- Study of the Antibacterial Potency of Electroactivated Solutions of Calcium Lactate and Calcium Ascorbate onACS omega · 2022Article
- Commensal bacteria contribute to the growth of multidrug-resistantFrontiers in microbiology · 2022Article
- Cereulide Exposure Caused Cytopathogenic Damages of Liver and Kidney in Mice.International journal of molecular sciences · 2021Article
- Review
- Characterization ofToxins · 2020Review
- Article
- Review
- First Insights Into Within Host Translocation of theFrontiers in microbiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus cereus is an opportunistic foodborne agent causing food poisoning and many infectious diseases. The heat-stable emetic toxin cereulide is one of the most prevalent toxins produced by pathogenic B. cereus, resulting in symptoms such as emesis and liver failure. In the present work, the toxicity and toxicokinetics of cereulide from an emetic B. cereus isolate (CAU45) of raw milk were evaluated. The production of cereulide was tested by a cytotoxicity test and enzyme immunoassay, and confirmed by the presence of the ces (cereulide synthetase) gene and the ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method. All results showed that the amount and toxicity of cereulide produced by CAU45 was 7 to 15.3 folds higher than the reference emetic B. cereus DSMZ 4312. Cereulide in plasma was collected at different time points after a single intravenous injection to evaluate its toxicokinetics in rabbits. The maximum concentration of cereulide was achieved in 2.6 ± 3.4 h after administration, with the elimination half-life of 10.8 ± 9.1 h, which expands our understanding of the toxic effects of cereulide. Together, it suggests that urgent sanitary practices are needed to eliminate emetic toxins and emetic B. cereus in raw milk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.