ReviewThe Clinical journal of pain2017
A Conceptual Framework for Understanding the Role of Adverse Childhood Experiences in Pediatric Chronic Pain.
Review in The Clinical journal of pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social Determinants of Health and Dysmenorrhea: A Systematic Review.The journal of pain · 2024Pooled it
- Investigating associations between allostatic load phenotypes and clinical impairment in youth with chronic pain.Brain, behavior, & immunity - health · 2026Article
- Impact of adverse life experiences on pain, depression, anxiety, and comorbidities: a youth longitudinal sample.Pain reports · 2026Article
- Experience of Maltreatment Is Associated With Abdominal Pain Intensity and Health-Related Quality of Life in Children With Pain-Predominant Disorders of Gut-Brain Interaction.Neurogastroenterology and motility · 2026Article
- The role of sleep deficiency in the relationship between adverse childhood experiences and early adolescent pain outcomes.JCPP advances · 2025Article
- Association between adverse childhood experiences and health related quality of life in adult cancer survivors in the United States.Journal of cancer survivorship : research and practice · 2025Article
- The number of central nervous system-driven symptoms predicts subsequent chronic primary pain. Response to Br J Anaesth 2025; 135: 493-4 and 135: 495-6.British journal of anaesthesia · 2025Article
- Adverse childhood experiences and chronic pain in adolescent patients with depressive disorder: the mediating role of circadian rhythm disruption.BMC psychiatry · 2025Article
- Adverse Childhood Experiences and Health at Age 50 Years in the National Child Development Study.JAMA network open · 2025Article
- Adverse childhood experiences and multisite pain among adolescents in the United States.Pain reports · 2025Article
- Adverse childhood experiences, brain efficiency, and the development of pain symptoms in youth.European journal of pain (London, England) · 2025Article
- The associations between adverse childhood experiences and body pain among middle-aged and older adults: findings from China.BMC public health · 2024Article
- Gender Diversity Among Youth Attending an Intensive Interdisciplinary Pain Treatment Program.Journal of clinical psychology in medical settings · 2024Article
- Review
- Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms.Nature reviews. Neurology · 2024Review
- Pain site persistence and changes from childhood to adolescence: a prospective cohort study.Pediatric research · 2024Article
- Relationships Between Recent Adverse Childhood Experiences (ACEs) and Somatic Symptoms in Adolescence.Journal of child and family studies · 2024Article
- The relationship between lifecourse traumatic events and pain in an older rural South African population: A cross-sectional study.PloS one · 2024Article
- Adverse childhood experiences and prescription opioid use during pregnancy: an analysis of the North and South Dakota PRAMS, 2019-2020.BMC pregnancy and childbirth · 2023Article
- Narrative Review of the Complex Interaction between Pain and Trauma in Children: A Focus on Biological Memory, Preclinical Data, and Epigenetic Processes.Children (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectivesThis review outlines a conceptual framework adapted from the biopsychosocial model of pain to examine the relationship between adverse childhood experiences (ACEs) and chronic pain in youth to highlight the state of current research and guide future efforts.
methodsA review of the literature was performed in the areas of ACEs and health outcomes with general adult and pediatric populations in addition to studies within the pain literature. Potential relationships between ACEs, chronic pain, and its impact in youth are outlined and discussed.
resultsThe literature suggests an association between adverse outcomes of ACEs and chronic pain in children and adolescents although causal links have not been confirmed. However, ACEs are associated with multiple risk factors identified in the biopsychosocial model of pain, and may serve to exacerbate or confer heightened risk for pain and poor outcomes. DISCUSSION: Adverse experiences in childhood may be associated with greater risk for the development/maintenance of chronic pain in youth. More research is needed on ACEs and how they uniquely affect the biopsychosocial mechanisms underlying chronic pain in children throughout the lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.