ArticlePloS one2016
Functional Relationship between Sucrose and a Cariogenic Biofilm Formation.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Antimicrobial Effect of Fluoride-Generating Nonthermal Atmospheric Plasmas on In Vitro Triple-Species Oral Biofilms.Journal of functional biomaterials · 2026Article
- Optical Attenuation Analysis of Biofilm Formation on Dental Prostheses Using Time-Domain Optical Coherence Tomography and Atomic Force Microscopy.Dentistry journal · 2026Article
- Phytosphingosine disrupts dual-species oral biofilms and attenuates LPS-induced pro-inflammatory responses in human gingival fibroblasts.Scientific reports · 2026Article
- Role of sucrose-dependent exopolysaccharides in the biofilm development ofApplied and environmental microbiology · 2026Article
- The oral microbiome as a regulatory hub for systemic health: a systematic review of mechanistic links and clinical implications.Journal of oral microbiology · 2026Review
- Mechanisms of caries induced by sugars: a narratives review from microbial metabolism to oral ecological imbalance and public health strategies for caries prevention.Frontiers in cellular and infection microbiology · 2026Review
- Impact of hydrogen peroxide photolysis on viable bacterial count and composition of in vivo dental biofilm-an ex vivo study.BMC oral health · 2025Article
- Synergistic effects of bacteria, enzymes, and cyclic mechanical stresses on the bond strength of composite restorations.Biomaterials advances · 2025Article
- Article
- Antimicrobial and antibiofilm activities of Brazilian organic honey against oral microorganisms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Effects of Sucrose and Farnesol on Biofilm Formation byMicroorganisms · 2024Article
- Evaluation of Functional Properties of Some Lactic Acid Bacteria Strains for Probiotic Applications in Apiculture.Microorganisms · 2024Article
- Alteration of oral microbial biofilms by sweeteners.Biofilm · 2024Review
- Metal leakage from orthodontic appliances chemically alters enamel surface during experimental in vitro simulated treatment.Scientific reports · 2024Article
- Inhibitory effect of helium cold atmospheric plasma on cariogenic biofilms.Journal of oral microbiology · 2024Article
- Sucrose-mediated formation and adhesion strength ofBiofilm · 2023Article
- Formation of Biofilm byFrontiers in microbiology · 2022Article
- Establishment of novel in vitro culture system with the ability to reproduce oral biofilm formation on dental materials.Scientific reports · 2021Article
- Combined effect of starch and sucrose on carbonic anhydrase VI activity in saliva and biofilm of children with early childhood caries. Exposure to starch and sucrose alters carbonic anhydrase VI activity in saliva and biofilm.Clinical oral investigations · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sucrose is an important dietary factor in cariogenic biofilm formation and subsequent initiation of dental caries. This study investigated the functional relationships between sucrose concentration and Streptococcus mutans adherence and biofilm formation. Changes in morphological characteristics of the biofilms with increasing sucrose concentration were also evaluated. S. mutans biofilms were formed on saliva-coated hydroxyapatite discs in culture medium containing 0, 0.05, 0.1, 0.5, 1, 2, 5, 10, 20, or 40% (w/v) sucrose. The adherence (in 4-hour biofilms) and biofilm composition (in 46-hour biofilms) of the biofilms were analyzed using microbiological, biochemical, laser scanning confocal fluorescence microscopic, and scanning electron microscopic methods. To determine the relationships, 2nd order polynomial curve fitting was performed. In this study, the influence of sucrose on bacterial adhesion, biofilm composition (dry weight, bacterial counts, and water-insoluble extracellular polysaccharide (EPS) content), and acidogenicity followed a 2nd order polynomial curve with concentration dependence, and the maximum effective concentrations (MECs) of sucrose ranged from 0.45 to 2.4%. The bacterial and EPS bio-volume and thickness in the biofilms also gradually increased and then decreased as sucrose concentration increased. Furthermore, the size and shape of the micro-colonies of the biofilms depended on the sucrose concentration. Around the MECs, the micro-colonies were bigger and more homogeneous than those at 0 and 40%, and were surrounded by enough EPSs to support their structure. These results suggest that the relationship between sucrose concentration and cariogenic biofilm formation in the oral cavity could be described by a functional relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.