ReviewExpert review of neurotherapeutics2016
Extinction learning in childhood anxiety disorders, obsessive compulsive disorder and post-traumatic stress disorder: implications for treatment.
Review in Expert review of neurotherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimising Exposure for Children and Adolescents with Anxiety, OCD and PTSD: A Systematic Review.Clinical child and family psychology review · 2021Pooled it
- Neurobiological Signatures of Dyadic Transmission of Fear Extinction in Adolescent Trauma Exposure and Posttraumatic Stress.Biological psychiatry global open science · 2026Article
- Network Structure of Post-Traumatic Stress and Social/Emotional/Behavioral Difficulties in a Post-Earthquake Child and Adolescent Sample.European journal of investigation in health, psychology and education · 2025Article
- Using latent patient-centered fear extinction profiles to guide treatment in pediatric OCD.Psychiatry research · 2025Article
- Advancing Obsessive-Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies.Brain sciences · 2025Review
- Using Inhibitory Learning Theories to Optimise Treatment for Children with Anxiety Disorders.Current topics in behavioral neurosciences · 2025Review
- Fear-potentiated startle reveals diminished threat extinction in pathological anxiety.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Behavioral Activation as a Principle-Based Treatment: Developments from a Multi-Site Collaboration to Advance Adolescent Depression Treatment.Evidence-based practice in child and adolescent mental health · 2023Article
- Interpretation Bias and Anticipated Distress in the Face of Ambiguity: Predictors of Change in Cognitive Behavioral Therapy for Youth Anxiety.Child psychiatry and human development · 2022Article
- High vagal tone and rapid extinction learning as potential transdiagnostic protective factors following childhood violence exposure.Developmental psychobiology · 2021Article
- Safety learning during development: Implications for development of psychopathology.Behavioural brain research · 2021Review
- Alterations in fear extinction neural circuitry and fear-related behavior linked to trauma exposure in children.Behavioural brain research · 2021Article
- Conceptualizing eating disorder psychopathology using an anxiety disorders framework: Evidence and implications for exposure-based clinical research.Clinical psychology review · 2021Review
- Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder.The American journal of psychiatry · 2021Review
- Psychiatric comorbidity of developmental trauma disorder and posttraumatic Stress disorder: findings from the DTD field trial replication (DTDFT-R).European journal of psychotraumatology · 2021Article
- Activation of mineralocorticoid receptors facilitate the acquisition of fear memory extinction and impair the generalization of fear memory in diabetic animals.Psychopharmacology · 2020Article
- Adolescent Vulnerability to Heightened Emotional Reactivity and Anxiety After Brief Exposure to an Obesogenic Diet.Frontiers in neuroscience · 2020Article
- Fear conditioning and extinction in anxious youth, offspring at-risk for anxiety and healthy comparisons: An fMRI study.Biological psychology · 2019Article
- Chronic harsh parenting and anxiety associations with fear circuitry function in healthy adolescents: A preliminary study.Biological psychology · 2019Article
- Mechanisms linking childhood adversity with psychopathology: Learning as an intervention target.Behaviour research and therapy · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionThreat conditioning and extinction play an important role in anxiety disorders, obsessive compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). Although these conditions commonly affect children, threat conditioning and extinction have been primarily studied in adults. However, differences in phenomenology and neural architecture prohibit the generalization of adult findings to youth. AREAS COVERED: A comprehensive literature search using PubMed and PsycInfo was conducted to identify studies that have used differential conditioning tasks to examine threat acquisition and extinction in youth. The information obtained from this review helps to clarify the influence of these processes on the etiology and treatment of youth with OCD, PTSD and other anxiety disorders. Thirty studies of threat conditioning and extinction were identified Expert commentary: Youth with anxiety disorders, OCD, and PTSD have largely comparable threat acquisition relative to unaffected controls, with some distinctions noted for youth with PTSD or youth who have suffered maltreatment. However, impaired extinction was consistently observed across youth with these disorders and appears to be consistent with deficiencies in inhibitory learning. Incorporating strategies to improve inhibitory learning may improve extinction learning within extinction-based treatments like cognitive behavioral therapy (CBT). Strategies to improve inhibitory learning in CBT are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.