ArticleOpen access Macedonian journal of medical sciences2016
Effects of Hormone Replacement Therapy on Insulin Resistance in Postmenopausal Diabetic Women.
Article in Open access Macedonian journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Hormone therapy and insulin resistance in non-diabetic postmenopausal women: a systematic review and meta-analysis.Climacteric : the journal of the International Menopause Society · 2025Pooled it
- Impact of diabetes mellitus on the menopausal experience: A scoping review.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Menopause hormone therapy and type 2 diabetes risk and prognosis: systematic review and meta-analyses.Diabetologia · 2026Review
- The impact of hormone replacement therapy on cardiovascular health in postmenopausal women: a narrative review.Frontiers in reproductive health · 2026Review
- The Role of Estrogen across Multiple Disease Mechanisms.Current issues in molecular biology · 2024Review
- Function and expression of N-acetyltransferases 1 and 2 are altered in lymphocytes in type 2 diabetes and obesity.Biochemistry and biophysics reports · 2024Article
- Reproductive risk factors across the female lifecourse and later metabolic health.Cell metabolism · 2024Review
- Nomogram for Predicting Hypoglycemia in Type 2 Diabetes Mellitus Patients Treated with Insulin Pump During Enteral Nutrition.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Timing Matters: Effects of Early and Late Estrogen Replacement Therapy on Glucose Metabolism and Vascular Reactivity in Ovariectomized Aged Wistar Rats.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2023Article
- Insight into genetic, biological, and environmental determinants of sexual-dimorphism in type 2 diabetes and glucose-related traits.Frontiers in cardiovascular medicine · 2022Review
- Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities.Nature reviews. Endocrinology · 2022Review
- Analyzing the drivers of cancer relapse: hypocalcemia and iron absorption in hormone-dependent female cancers.American journal of translational research · 2022Article
- Serum 25-hydroxyvitamin D and hypertension in premenopausal and postmenopausal women: National Health and Nutrition Examination Surveys 2007-2010.Public health nutrition · 2020Article
- An analysis of the associations between gender and metabolic syndrome components in Korean adults: a national cross-sectional study.BMC endocrine disorders · 2019Article
- Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (Open access Macedonian journal of medical sciences · 2019Article
- The Effect of Puguntano Leaf Extract (Open access Macedonian journal of medical sciences · 2019Article
- Genistein preserves the lungs of ovariectomized diabetic rats: addition to apoptotic and inflammatory markers in the lung.Iranian journal of basic medical sciences · 2017Article
- A cross-sectional study on the associations of insulin resistance with sex hormone, abnormal lipid metabolism in T2DM and IGT patients.Medicine · 2017Observational
- Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier.Journal of Alzheimer's disease : JAD · 2017Review
- Impact of menopause and diabetes on atherogenic lipid profile: is it worth to analyse lipoprotein subfractions to assess cardiovascular risk in women?Diabetology & metabolic syndrome · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin resistance (IR) is closely associated with diabetes mellitus. On the other hand, increased visceral fat in menopause is also associated with IR, which makes postmenopausal diabetic women in a big risk for cardiovascular diseases. There are conflicting reports about the effects on hormone replacement therapy (HRT) on IR.
aimThe aim of the study was to investigate the effects of HRT on IR.
methodsA total of 40 postmenopausal women with type 2 diabetes were enrolled and followed for 12 months. Half of them were assigned to take HRT, while the other half made the control group. Fasting plasma glucose (FPG) and insulinemia were measured in both groups at baseline and after 12 months. IR was represented by Homeostatic model assessment for IR (HOMA-IR).
resultsHRT was associated with significant decrease in HOMA-IR, FPG and insulinemia in the examined group. There was no significant reduction in FPG and no significant increase in insulinemia levels and HOMA-IR values in control group after 12 months.
conclusionHRT was associated with statistically signifficant increase of insulin sensitivity. Larger clinical trials will be necessary to understand whether HRT may improve insulin resistance and glucose homeostasis in women with diabetes, especially when given shortly after entering menopause.
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