ArticleKorean circulation journal2016
Obesity and Hypertension in Association with Diastolic Dysfunction Could Reduce Exercise Capacity.
Article in Korean circulation journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Experimental Models for Studying Cardiovascular Dysfunction in Metabolic Syndrome.Handbook of experimental pharmacology · 2026Review
- Association Between Physical Activity Dose and Mental Health Among Stroke Survivors.Journal of the American Heart Association · 2025Article
- Left atrial strain improves echocardiographic classification of diastolic function in patients with metabolic syndrome and overweight-obesity.International journal of cardiology · 2022Article
- Additive Effects of Obesity on Myocardial Microcirculation and Left Ventricular Deformation in Essential Hypertension: A Contrast-Enhanced Cardiac Magnetic Resonance Imaging Study.Frontiers in cardiovascular medicine · 2022Article
- UCP3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin II-Induced Hypertension.Journal of the American Heart Association · 2021Article
- Early age at menarche and metabolic cardiovascular risk factors: mediation by body composition in adulthood.Scientific reports · 2021Article
- Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity.International journal of cardiology. Heart & vasculature · 2019Article
- Exercise impedance cardiography reveals impaired hemodynamic responses to exercise in hypertensives with dyspnea.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Metabolic syndrome, not menopause, is a risk factor for hypertension in peri-menopausal women.Clinical hypertension · 2018Article
- Beneficial Effects of Bariatric Surgery on Cardiac Structure and Function in Obesity.Obesity surgery · 2017Article
- Voluntary stand-up physical activity enhances endurance exercise capacity in rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesEmpirical evidence is lacking on the cumulative disease burden of obesity and hypertension and its impact on cardiac function and exercise capacity. The purpose of this study was to determine whether the presence of obesity and hypertension together was associated with cardiac dysfunction and exercise capacity. SUBJECTS AND
methodsUsing a retrospective study design, medical records were reviewed for echocardiographic and treadmill exercise stress test data. Subjects were grouped according to four categories: normal control, obese, hypertensive, or obese and hypertensive.
resultsObese, hypertensive persons showed significantly lower Ea and E/A ratio and greater E/Ea ratio, deceleration time, left ventricular (LV) mass, and LV mass index compared to their counter parts (normal control, obese and/or hypertensive) (all p<0.05), after controlling for age and sex. After controlling for age and sex, significant differences in exercise capacity indices were found, with the obese group having shorter exercise time, lower metabolic equivalents, and lower maximal oxygen uptake than the normal control, hypertensive, or both groups (all p<0.05). The hypertensive or obese and hypertensive group had greater maximal blood pressure compared with the normal control group (all p<0.001). Obese and hypertensive persons were approximately three times more likely to have diastolic dysfunction (odd ratio=2.96, p=0.001), when compared to the reference group (normotensive, non-obese, or hypertensive only persons).
conclusionDiastolic dysfunction was associated with obesity and/or hypertension. The cumulative risk of obesity and hypertension and their impact on diastolic dysfunction which could be modifiable could reduce exercise capacity.
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Registered trials
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